Maintaining the integrity of the gastrointestinal tract, despite the continual presence of
microbial flora and injurious agents, is essential. Epithelial continuity depends on a family of …

Trefoil factor family peptides (TFF1, TFF2, TFF3) are typically co-secreted together with
mucins. Tff1 represents a gastric tumor suppressor gene in mice. TFFs are also synthesized …

Trefoil factor family peptides (TFF1, TFF2, TFF3), together with mucins, are typical exocrine
products of mucous epithelia. Here, they act as a gastric tumor suppressor (TFF1) or they …

Abstract Trefoil factor 3 (TFF3) is the last small-molecule peptide found in the trefoil factor
family, which is mainly secreted by intestinal goblet cells and exerts mucosal repair effect in …

Abstract CD11b+ Gr-1+ myeloid-derived suppressor cells (MDSCs) expand in the spleen
during cancer and promote progression through suppression of cytotoxic T cells. An anti …

TFF peptides are involved in mucosal maintenance and repair through motogenic and
antiapoptotic activities. These peptides are overexpressed during inflammatory processes …

Intestinal epithelial cells (IEC) have important functions in nutrient absorption, barrier
integrity, regeneration, pathogen-sensing, and mucus secretion. Goblet cells are a …

The peptide TFF2 (formerly 'spasmolytic polypeptide'), a member of the trefoil factor family
(TFF) containing two TFF domains, is mainly expressed together with the mucin MUC6 in the …

The “TFF domain” is an ancient cysteine-rich shuffled module forming the basic unit for the
family of secretory TFF peptides (formerly P-domain peptides and trefoil factors). It is also an …

The secreted trefoil factor family 2 (TFF2) protein contributes to the protection of the
gastrointestinal mucosa from injury by strengthening and stabilizing mucin gels, stimulating …