Fucoidan/hyaluronic acid cross-linked zein nanoparticles loaded with fisetin as a novel targeted nanotherapy for oral cancer
Fisetin (FS) is an anticancer drug having potential role in oral tumors management.
However, its clinical application is limited due to its hydrophobicity and instability. Bioactive …
However, its clinical application is limited due to its hydrophobicity and instability. Bioactive …
[HTML][HTML] Vitamin B12 as a cholinergic system modulator and blood brain barrier integrity restorer in Alzheimer's disease
NS El-Mezayen, RA Abd el Moneim… - European Journal of …, 2022 - Elsevier
So far, the cholinergic hypothesis of Alzheimer's disease (AD) remains the fundamental
explanation for the complex etiopathology of AD. However, therapeutics raising synaptic …
explanation for the complex etiopathology of AD. However, therapeutics raising synaptic …
Novel celecoxib-loaded chitosan-fucoidan nanoparticles as potential immunotherapy for oral squamous cell carcinoma: Mechanistic insights
AA Mabrouk, NS El-Mezayen, AK Awaad… - Journal of Drug Delivery …, 2023 - Elsevier
Celecoxib (CXB), a selective COX-2 inhibitor, is a component of triple-oral-metronomic-
chemotherapy. However, chronic CXB utilization in high doses could bring about major …
chemotherapy. However, chronic CXB utilization in high doses could bring about major …
Alleviation of liver cirrhosis and associated portal-hypertension by Astragalus species in relation to their UPLC-MS/MS metabolic profiles: a mechanistic study
Liver cirrhosis is a late-stage liver disease characterized by excessive fibrous deposition
triggering portal-hypertension (PH); the prime restrainer for cirrhosis-related complications …
triggering portal-hypertension (PH); the prime restrainer for cirrhosis-related complications …
A high throughput screening assay for human Thyroperoxidase inhibitors
H Dong, KP Friedman, A Filiatreault, EM Thomson… - Toxicology in Vitro, 2024 - Elsevier
Rapid, human relevant assays are needed to assess potential hazards of the many
chemicals in commerce. An assay of thyroid peroxidase (TPO) inhibition, using the substrate …
chemicals in commerce. An assay of thyroid peroxidase (TPO) inhibition, using the substrate …
Comprehensive transcriptomic and metabolomic profiling reveals the differences between alfalfa sprouts germinated with or without light exposure
K Zhang, H Li, T Zhang, S Wang, L Liu… - Frontiers in Plant …, 2022 - frontiersin.org
Alfalfa sprouts are among the most nutritionally rich foods, and light exposure is a critical
factor in determining their biomass and quality. However, detailed metabolic and molecular …
factor in determining their biomass and quality. However, detailed metabolic and molecular …
Metabolomic insights into the therapeutic mechanisms of costus (Saussurea costus (Falc.) Lipsch.) root extract in propylthiouracil-induced hypothyroidism rat model
HM Dawood, NM Barghouth, NS El-Mezayen… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Saussurea costus (Falc.) Lipschitz. is one of the
most reputed medicinal plants as a traditional medicine in the Arab and Middle East regions …
most reputed medicinal plants as a traditional medicine in the Arab and Middle East regions …
Zolmitriptan niosomal transdermal patches: combating migraine via epigenetic and endocannabinoid pathways and reversal of migraine hypercoagulability
NAH Abou Youssef, GS Labib, AA Kassem… - Drug Delivery and …, 2024 - Springer
Conventional zolmitriptan (ZOL) has limited oral bioavailability, many adverse effects, and
poor membrane penetrability that negatively influences its accessibility to its 5-HT 1B/1D …
poor membrane penetrability that negatively influences its accessibility to its 5-HT 1B/1D …
In Vitro and In Silico Anti-Picornavirus Triterpene Alkanoic Acid Ester from Saudi Collection of Rhazya stricta Decne
MS Abdel-Kader, FS Almutib, AF Aldosari, GA Soliman… - Metabolites, 2023 - mdpi.com
The total alcohol extract obtained from the aerial parts of R. stricta and fractions of the liquid–
liquid fractionation process were tested against picornavirus-causing foot-and-mouth …
liquid fractionation process were tested against picornavirus-causing foot-and-mouth …
Metabolomic Analysis of Key Metabolites and Their Pathways Revealed the Response of Alfalfa (Medicago sativa L.) Root Exudates to rac-GR24 under Drought …
Y Yang, M Gu, J Lu, X Li, D Liu, L Wang - Plants, 2023 - mdpi.com
The rac-GR24, an artificial analog of strigolactone, is known for its roles in inhibiting
branches, and previous studies have reported that it has a certain mechanism to relieve …
branches, and previous studies have reported that it has a certain mechanism to relieve …