Fucoidan/hyaluronic acid cross-linked zein nanoparticles loaded with fisetin as a novel targeted nanotherapy for oral cancer

MA Moustafa, WM El-Refaie, YSR Elnaggar… - International Journal of …, 2023 - Elsevier
Fisetin (FS) is an anticancer drug having potential role in oral tumors management.
However, its clinical application is limited due to its hydrophobicity and instability. Bioactive …

[HTML][HTML] Vitamin B12 as a cholinergic system modulator and blood brain barrier integrity restorer in Alzheimer's disease

NS El-Mezayen, RA Abd el Moneim… - European Journal of …, 2022 - Elsevier
So far, the cholinergic hypothesis of Alzheimer's disease (AD) remains the fundamental
explanation for the complex etiopathology of AD. However, therapeutics raising synaptic …

Novel celecoxib-loaded chitosan-fucoidan nanoparticles as potential immunotherapy for oral squamous cell carcinoma: Mechanistic insights

AA Mabrouk, NS El-Mezayen, AK Awaad… - Journal of Drug Delivery …, 2023 - Elsevier
Celecoxib (CXB), a selective COX-2 inhibitor, is a component of triple-oral-metronomic-
chemotherapy. However, chronic CXB utilization in high doses could bring about major …

Alleviation of liver cirrhosis and associated portal-hypertension by Astragalus species in relation to their UPLC-MS/MS metabolic profiles: a mechanistic study

RS Ibrahim, NS El-Mezayen, AA El‐Banna - Scientific Reports, 2022 - nature.com
Liver cirrhosis is a late-stage liver disease characterized by excessive fibrous deposition
triggering portal-hypertension (PH); the prime restrainer for cirrhosis-related complications …

A high throughput screening assay for human Thyroperoxidase inhibitors

H Dong, KP Friedman, A Filiatreault, EM Thomson… - Toxicology in Vitro, 2024 - Elsevier
Rapid, human relevant assays are needed to assess potential hazards of the many
chemicals in commerce. An assay of thyroid peroxidase (TPO) inhibition, using the substrate …

Comprehensive transcriptomic and metabolomic profiling reveals the differences between alfalfa sprouts germinated with or without light exposure

K Zhang, H Li, T Zhang, S Wang, L Liu… - Frontiers in Plant …, 2022 - frontiersin.org
Alfalfa sprouts are among the most nutritionally rich foods, and light exposure is a critical
factor in determining their biomass and quality. However, detailed metabolic and molecular …

Metabolomic insights into the therapeutic mechanisms of costus (Saussurea costus (Falc.) Lipsch.) root extract in propylthiouracil-induced hypothyroidism rat model

HM Dawood, NM Barghouth, NS El-Mezayen… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Saussurea costus (Falc.) Lipschitz. is one of the
most reputed medicinal plants as a traditional medicine in the Arab and Middle East regions …

Zolmitriptan niosomal transdermal patches: combating migraine via epigenetic and endocannabinoid pathways and reversal of migraine hypercoagulability

NAH Abou Youssef, GS Labib, AA Kassem… - Drug Delivery and …, 2024 - Springer
Conventional zolmitriptan (ZOL) has limited oral bioavailability, many adverse effects, and
poor membrane penetrability that negatively influences its accessibility to its 5-HT 1B/1D …

In Vitro and In Silico Anti-Picornavirus Triterpene Alkanoic Acid Ester from Saudi Collection of Rhazya stricta Decne

MS Abdel-Kader, FS Almutib, AF Aldosari, GA Soliman… - Metabolites, 2023 - mdpi.com
The total alcohol extract obtained from the aerial parts of R. stricta and fractions of the liquid–
liquid fractionation process were tested against picornavirus-causing foot-and-mouth …

Metabolomic Analysis of Key Metabolites and Their Pathways Revealed the Response of Alfalfa (Medicago sativa L.) Root Exudates to rac-GR24 under Drought …

Y Yang, M Gu, J Lu, X Li, D Liu, L Wang - Plants, 2023 - mdpi.com
The rac-GR24, an artificial analog of strigolactone, is known for its roles in inhibiting
branches, and previous studies have reported that it has a certain mechanism to relieve …