Mitochondrial biogenesis and mitochondrial DNA (mtDNA) maintenance depend on
coordinated expression of genes in the nucleus and mitochondria. A variety of intracellular …

Mitochondria do not only produce less ATP, but they also increase the production of reactive
oxygen species (ROS) as byproducts of aerobic metabolism in the aging tissues of the …

Extracellular acidification occurs in inflamed tissue and the tumor microenvironment;
however, a systematic study on how pH sensing contributes to tissue homeostasis is lacking …

Key points Reactive oxygen species (ROS) and nitric oxide (NO) regulate exercise‐induced
nuclear factor erythroid 2‐related factor 2 (NFE2L2) expression in skeletal muscle. NFE2L2 …

Mitochondrial respiratory function is impaired in the target tissues of patients with
mitochondrial diseases and declines with age in various human tissues. It is generally …

Mitochondria are the major ATP producer of the mammalian cell. Moreover, mitochondria
are also the main intracellular source and target of reactive oxygen species (ROS) that are …

Abnormal proliferation of mitochondria generally occurs in muscle of aged individuals and
patients with mitochondrial myopathy. An increase in the mitochondrial DNA (mtDNA) copy …

Using the mRNA differential display technique, seven cDNAs have been isolated that are
rapidly induced when cultured tobacco (Nicotiana tabacum) cells are treated with the …

Respiratory function of mitochondria is compromised in aging human tissues and severely
impaired in the patients with mitochondrial disease. A wide spectrum of mitochondrial DNA …

Various intracellular organelles, such as lysosomes, mitochondria, nuclei, and
cytoskeletons, change during replicative senescence, but the utility of these changes as …