Following Alzheimer's, Parkinson's disease (PD) is the second-most common
neurodegenerative disorder, sharing an unclear pathophysiology, a multifactorial profile …

Abnormal accumulation of aggregated α-synuclein (α-Syn) is seen in a variety of
neurodegenerative diseases, including Parkinson's disease (PD), multiple system atrophy …

The generation of α-synuclein (α-syn) truncations from incomplete proteolysis plays a
significant role in the pathogenesis of Parkinson's disease. It is well established that C …

Abstract α-Synuclein (α-syn) is the main protein component of Lewy bodies, the major
pathological hallmarks of Parkinson's disease (PD). C-terminally truncated α-syn is found in …

Parkinson's disease is associated with the aberrant aggregation of α-synuclein. Although the
causes of this process are still unclear, post-translational modifications of α-synuclein are …

α-Synuclein is a small neuronal protein enriched at presynaptic termini. It is hypothesized to
play a role in neurotransmitter release and synaptic vesicle cycling, while the formation of α …

Abstract The aggregation of Alpha Synuclein (α-Syn) into fibrils is associated with the
pathology of several neurodegenerative diseases. Pathologic aggregates of α-Syn adopt …

The ability of Adenosine Triphosphate (ATP) to modulate protein solubility establishes a
critical link between ATP homeostasis and proteinopathies, such as Parkinson's (PD). The …

Amyloid fibrils may adopt different morphologies depending on the solution conditions and
the protein sequence. Here, we show that two chemically identical but morphologically …

Abstract α‐Synuclein (αS) aggregation is the main neurological hallmark of a group of
debilitating neurodegenerative disorders, collectively referred to as synucleinopathies, of …