Metastatic dissemination of solid tumors, a leading cause of cancer-related mortality,
underscores the urgent need for enhanced insights into the molecular and cellular …

The ability of cancer cells to suppress apoptosis is critical for carcinogenesis. The BCL2
family proteins comprise the sentinel network that regulates the mitochondrial or intrinsic …

Mitochondrial division is essential for mitosis and metazoan development, but a mechanistic
role in cancer biology remains unknown. Here, we examine the direct effects of oncogenic …

Malignant melanoma is one of the most difficult cancers to treat due to its resistance to
chemotherapy. Despite recent successes with BRAF inhibitors and immune checkpoint …

The dynamic interplay between pro-death and pro-survival Bcl-2 family proteins is
responsible for a cell's fate. Due to the recognized relevance of this family in cancer …

Cellular commitment to the mitochondrial pathway of apoptosis is accomplished when
proapoptotic B cell chronic lymphocytic leukemia/lymphoma (BCL)-2 proteins compromise …

BH3 mimetics, targeting the Bcl-2 family anti-apoptotic proteins, represent a promising
therapeutic opportunity in cancers. ABT-199, the first specific Bcl-2 inhibitor, was approved …

Spinal cord injury (SCI) leads to neuronal death resulting in central nervous system (CNS)
dysfunction; however, the pathogenesis is still poorly understood. Melatonin (MT), a …

Accumulating evidences indicate that microRNAs play a vital role in regulating tumor
progression. However, the roles of miR-148b in hepatocellular carcinoma (HCC) are still …

Background Macrophages take center stage in the tumor microenvironment, a niche
composed of extracellular matrix and a heterogeneous group of cells, including immune …