Toll-like receptors (TLRs) are a class of proteins that recognize pathogen-associated
molecular patterns (PAMPs) and damaged-associated molecular patterns (DAMPs), and …

Hepatitis B virus infection affects over 250 million chronic carriers, causing more than
800,000 deaths annually, although a safe and effective vaccine is available. Currently used …

A total of 20 1, 2, 4-triazole Mannich base derivatives bearing the 6-
fluoroquinazolinylpiperidinyl moiety were designed, synthesized, and evaluated as …

Toll-like receptor 8 (TLR8) recognizes pathogen-derived single-stranded RNA fragments to
trigger innate and adaptive immune responses. Chronic hepatitis B (CHB) is associated with …

Quinazoline and its derivatives have drawn much attention in the development of potential
antitumor agents. Here, we synthesized a series of 1, 2, 3-triazole derivatives of quinazoline …

Toll-like receptors (TLRs) are members of a large family of evolutionarily conserved pattern
recognition receptors (PRRs), which serve as key components of the innate immune system …

Several synthetic heterocyclic small molecules like imiquimod, resiquimod, CL097, CL075,
bromopirone, tilorone, loxoribine and isatoribine demonstrated TLR7/8 agonistic activity and …

The innate immune system recognizes conserved features of viral and microbial pathogens
through pattern recognition receptors (PRRs). Toll-like receptors (TLR s) are one type of …

Small molecule toll-like receptor (TLR) 7 agonists have gathered considerable interest as
promising therapeutic agents for applications in cancer immunotherapy. Herein, we describe …

Toll-like receptors (TLRs) 7 and 8 play an important role in the activation of innate immune
cells in mammals. These evolutionarily conserved receptors serve as important sentinels in …