The magnitude and quality of the germinal center (GC) response decline with age, resulting
in poor vaccine-induced immunity in older individuals. A functional GC requires the co …

Germinal Centres (GCs) are transient structures in secondary lymphoid organs, where
affinity maturation of B cells takes place following an infection. While GCs are responsible for …

A universal vaccine against influenza would ideally generate protective immune responses
that are not only broadly reactive against multiple influenza strains but also long-lasting …

Germinal centers (GC) are microanatomical lymphoid structures where affinity-matured
memory B cells and long-lived bone marrow plasma cells are primarily generated. It is …

Serology is the measurement of antibodies to specific infectious agents in serum from one or
more individuals, to determine whether they have been infected with, or vaccinated against …

Germinal centers (GCs) play a central role in generating an effective immune response
against infectious pathogens, and failures in their regulating mechanisms can lead to the …

Follicular dendritic cells (FDCs) retain immune complexes (ICs) for prolonged time periods
and are important for germinal center (GC) reactions. ICs undergo periodic cycling in FDCs …

Germinal centers (GCs) are specialized compartments within the secondary lymphoid
organs where B cells proliferate, differentiate, and mutate their antibody genes in response …

Germinal centers (GCs) are transient structures where affinity maturation of B cells gives rise
to high affinity plasma and memory cells. The mechanism of GC shutdown is unclear …

Antigen-specific antibody infusion is known to enhance or suppress germinal center (GC)
responses depending on the affinity of the infusion. We hypothesized that infusing …