Interstitial fluid and lymph formation and transport: physiological regulation and roles in inflammation and cancer
The interstitium describes the fluid, proteins, solutes, and the extracellular matrix (ECM) that
comprise the cellular microenvironment in tissues. Its alterations are fundamental to …
comprise the cellular microenvironment in tissues. Its alterations are fundamental to …
Lymphatic and interstitial flow in the tumour microenvironment: linking mechanobiology with immunity
Tumours often engage the lymphatic system in order to invade and metastasize. The tumour-
draining lymph node may be an immune-privileged site that protects the tumour from host …
draining lymph node may be an immune-privileged site that protects the tumour from host …
Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection
LT Baxter, RK Jain - Microvascular research, 1989 - Elsevier
A general theoretical framework for transvascular exchange and extravascular transport of
fluid and macromolecules in tumors is developed. The resulting equations are applied to the …
fluid and macromolecules in tumors is developed. The resulting equations are applied to the …
Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy
Y Boucher, LT Baxter, RK Jain - Cancer research, 1990 - AACR
High interstitial fluid pressure (IFP) in solid tumors is associated with reduced blood flow as
well as inadequate delivery of therapeutic agents such as monoclonal antibodies. In the …
well as inadequate delivery of therapeutic agents such as monoclonal antibodies. In the …
Transport of molecules across tumor vasculature
RK Jain - Cancer and Metastasis Reviews, 1987 - Springer
The vascular-extravascular exchange of fluid and solute molecules in a tissue is determined
by three transport parameters (vascular permeability, P, hydraulic conductivity, L p, and …
by three transport parameters (vascular permeability, P, hydraulic conductivity, L p, and …
Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse
Y Boucher, RK Jain - Cancer research, 1992 - AACR
The interstitial fluid pressure (IFP) has been found to be as high as 20 to 50 mm Hg in both
experimental and human solid tumors. While the IFP is an important determinant of the …
experimental and human solid tumors. While the IFP is an important determinant of the …
Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors
RK Jain - Cancer research, 1990 - AACR
The efficacy in cancer treatment of monoclonal antibodies or other macromolecules bound
to radionuclides, chemotherapeutic agents, toxins, enzymes, growth factors, or effector …
to radionuclides, chemotherapeutic agents, toxins, enzymes, growth factors, or effector …
Vascular and interstitial barriers to delivery of therapeutic agents in tumors
RK Jain - Cancer and Metastasis Reviews, 1990 - Springer
The efficacy in cancer treatment of novel therapeutic agents such as monoclonal antibodies,
cytokines and effector cells has been limited by their inability to reach their target in vivo in …
cytokines and effector cells has been limited by their inability to reach their target in vivo in …
Interstitial pressure in pancreatic ductal adenocarcinoma is dominated by a gel-fluid phase
CC DuFort, KE DelGiorno, MA Carlson, RJ Osgood… - Biophysical journal, 2016 - cell.com
Elevated interstitial fluid pressure can present a substantial barrier to drug delivery in solid
tumors. This is particularly true of pancreatic ductal adenocarcinoma, a highly lethal disease …
tumors. This is particularly true of pancreatic ductal adenocarcinoma, a highly lethal disease …
Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors
Most solid malignancies display interstitial hypertension and a poor uptake of anticancer
drugs. Platelet-derived growth factor (PDGF) and the cognate tyrosine kinase receptors are …
drugs. Platelet-derived growth factor (PDGF) and the cognate tyrosine kinase receptors are …