[HTML][HTML] Toll-like receptor signaling and its role in cell-mediated immunity
Innate immunity is the first defense system against invading pathogens. Toll-like receptors
(TLRs) are well-defined pattern recognition receptors responsible for pathogen recognition …
(TLRs) are well-defined pattern recognition receptors responsible for pathogen recognition …
[HTML][HTML] Targeting toll-like receptors: promising therapeutic strategies for the management of sepsis-associated pathology and infectious diseases
A Savva, T Roger - Frontiers in immunology, 2013 - frontiersin.org
Toll-like receptors (TLRs) are pattern recognition receptors playing a fundamental role in
sensing microbial invasion and initiating innate and adaptive immune responses. TLRs are …
sensing microbial invasion and initiating innate and adaptive immune responses. TLRs are …
Novel drugs targeting Toll-like receptors for antiviral therapy
MC Patel, KA Shirey, LM Pletneva… - Future …, 2014 - Taylor & Francis
Toll-like receptors (TLRs) are sentinel receptors of the host innate immune system that
recognize conserved'pathogen-associated molecular patterns' of invading microbes …
recognize conserved'pathogen-associated molecular patterns' of invading microbes …
[HTML][HTML] Association of toll-like receptor polymorphisms with susceptibility to chikungunya virus infection
SK Dutta, A Tripathi - Virology, 2017 - Elsevier
Chikungunya virus (CHIKV) infection leads to activation of innate immune response by
triggering Toll-like receptor (TLR) pathways resulting in elevated cytokines and type-I …
triggering Toll-like receptor (TLR) pathways resulting in elevated cytokines and type-I …
Multidimensional immune profiling of cutaneous lupus erythematosus in vivo stratified by patient response to antimalarials
Objective The pathogenesis of cutaneous lupus erythematosus (CLE) is multifactorial, and
CLE is difficult to treat due to the heterogeneity of inflammatory processes among patients …
CLE is difficult to treat due to the heterogeneity of inflammatory processes among patients …
Toll-like receptors 7/8: a paradigm for the manipulation of immunologic reactions for immunotherapy
F Li, B Song, WF Zhou, LJ Chu - Viral Immunology, 2023 - liebertpub.com
The innate immune system recognizes conserved features of viral and microbial pathogens
through pattern recognition receptors (PRRs). Toll-like receptors (TLR s) are one type of …
through pattern recognition receptors (PRRs). Toll-like receptors (TLR s) are one type of …
Self-assembling peptide for co-delivery of HIV-1 CD8+ T cells epitope and Toll-like receptor 7/8 agonists R848 to induce maturation of monocyte derived dendritic cell …
Y Ding, J Liu, S Lu, J Igweze, W Xu, D Kuang… - Journal of controlled …, 2016 - Elsevier
Peptide based vaccine that incorporates one or several highly conserved CD8+ T cells
epitopes to induce potent cytotoxic T lymphocyte (CTL) response is desirable for some …
epitopes to induce potent cytotoxic T lymphocyte (CTL) response is desirable for some …
[HTML][HTML] Quinacrine suppresses tumor necrosis factor-α and IFN-α in dermatomyositis and cutaneous lupus erythematosus
P Alves, MM Bashir, M Wysocka, M Zeidi… - Journal of Investigative …, 2017 - Elsevier
Antimalarials are used to treat dermatomyositis (DM) and cutaneous lupus erythematosus
(CLE). Although hydroxychloroquine (HCQ) is frequently used, addition of quinacrine (QC) …
(CLE). Although hydroxychloroquine (HCQ) is frequently used, addition of quinacrine (QC) …
Advances in antiviral therapies targeting toll-like receptors
Introduction: Organisms have evolved a rapid and non-specific way to defend themselves
via Toll-like receptors (TLRs), which recognize specific signatures present on invading …
via Toll-like receptors (TLRs), which recognize specific signatures present on invading …
TLR8 ligation induces apoptosis of monocytic myeloid-derived suppressor cells
Myeloid-derived suppressor cells (MDSCs) accumulate in tumors and the peripheral blood
of cancer patients and demonstrate cancer-promoting activity across multiple tumor types. A …
of cancer patients and demonstrate cancer-promoting activity across multiple tumor types. A …