Autoimmune heparin‐induced thrombocytopenia (aHIT) indicates the presence in patients of
anti‐platelet factor 4 (PF4)–polyanion antibodies that are able to activate platelets strongly …

Key Clinical Points Heparin-Induced Thrombocytopenia Heparin-induced thrombocytopenia
(HIT) is characterized by a decrease in the platelet count of more than 50% from the highest …

Heparin-induced thrombocytopenia is an immune-mediated disorder caused by antibodies
that recognize complexes of platelet factor 4 and heparin. Thrombosis is a central and …

A clinically important adverse drug reaction, heparin-induced thrombocytopenia (HIT), is
induced by antibodies specific for complexes of the chemokine platelet factor 4 (PF4) and …

Bacterial adhesion to platelets is mediated via a range of strain-specific bacterial surface
proteins that bind to a variety of platelet receptors. It is unclear how these interactions lead to …

The tight electrostatic binding of the chemokine platelet factor 4 (PF4) to polyanions induces
heparin-induced thrombocytopenia, a prothrombotic adverse drug reaction caused by …

Heparin-induced thrombocytopenia (HIT) is a prothrombotic drug reaction caused by platelet-
activating IgG antibodies that recognize platelet factor 4 (PF4)/polyanion complexes. Platelet …

Life-threatening thrombotic events at unusual sites have been reported after vector-based
vaccinations against severe acute respiratory syndrome coronavirus 2. This phenomenon is …

Heparin-induced thrombocytopenia (HIT) and vaccine-induced immune thrombotic
thrombocytopenia (VITT) are highly prothrombotic (thrombosis frequency≥ 50%). Both are …

Knowledge on heparin-induced thrombocytopenia keeps increasing. Recent progress on
diagnosis and management as well as several discoveries concerning its pathogenesis …