[HTML][HTML] MicroRNA-based diagnosis and therapy
MicroRNAs (miRNAs) are a group of endogenous non-coding RNAs that regulate gene
expression. Alteration in miRNA expression results in changes in the profile of genes …
expression. Alteration in miRNA expression results in changes in the profile of genes …
Osteoporosis and the ageing skeleton
TJ Aspray, TR Hill - Biochemistry and cell biology of ageing: Part II clinical …, 2019 - Springer
Osteoporosis is a “skeletal disorder characterized by compromised bone strength
predisposing a person to an increased risk of fracture” which, in light of demographic …
predisposing a person to an increased risk of fracture” which, in light of demographic …
[HTML][HTML] How close are miRNAs from clinical practice? A perspective on the diagnostic and therapeutic market
E Bonneau, B Neveu, E Kostantin, GJ Tsongalis… - Ejifcc, 2019 - ncbi.nlm.nih.gov
The discovery of miRNAs in the mid-90s has changed the dogma of gene expression
regulation. Currently, miRNAs are the main theme of thousands of publications each year …
regulation. Currently, miRNAs are the main theme of thousands of publications each year …
[HTML][HTML] Diagnosis and management of bone fragility in diabetes: an emerging challenge
SL Ferrari, B Abrahamsen, N Napoli, K Akesson… - Osteoporosis …, 2018 - Springer
Fragility fractures are increasingly recognized as a complication of both type 1 and type 2
diabetes, with fracture risk that increases with disease duration and poor glycemic control …
diabetes, with fracture risk that increases with disease duration and poor glycemic control …
microRNA-382 as a tumor suppressor? Roles in tumorigenesis and clinical significance
MicroRNAs (miRNAs) are small single-stranded RNAs belonging to a class of non-coding
RNAs with an average length of 18–22 nucleotides. Although not able to encode any …
RNAs with an average length of 18–22 nucleotides. Although not able to encode any …
[HTML][HTML] Life-course genome-wide association study meta-analysis of total body BMD and assessment of age-specific effects
C Medina-Gomez, JP Kemp, K Trajanoska… - The American Journal of …, 2018 - cell.com
Bone mineral density (BMD) assessed by DXA is used to evaluate bone health. In children,
total body (TB) measurements are commonly used; in older individuals, BMD at the lumbar …
total body (TB) measurements are commonly used; in older individuals, BMD at the lumbar …
[HTML][HTML] Impact of diabetes mellitus on bone health
CE Murray, CM Coleman - International journal of molecular sciences, 2019 - mdpi.com
Long-term exposure to a diabetic environment leads to changes in bone metabolism and
impaired bone micro-architecture through a variety of mechanisms on molecular and …
impaired bone micro-architecture through a variety of mechanisms on molecular and …
Inflammageing and metaflammation: the yin and yang of type 2 diabetes
F Prattichizzo, V De Nigris, R Spiga, E Mancuso… - Ageing research …, 2018 - Elsevier
Type 2 diabetes mellitus (T2DM) is characterised by chronic low-grade inflammation,
recently referred to as 'metaflammation', a relevant factor contributing to the development of …
recently referred to as 'metaflammation', a relevant factor contributing to the development of …
Circulating microRNA signatures in patients with idiopathic and postmenopausal osteoporosis and fragility fractures
R Kocijan, C Muschitz, E Geiger… - The Journal of …, 2016 - academic.oup.com
Context: Established bone turnover markers do not reflect fracture risk in idiopathic male and
premenopausal osteoporosis and the role of microRNAs (miRNAs) in these patients is …
premenopausal osteoporosis and the role of microRNAs (miRNAs) in these patients is …
[HTML][HTML] Bone-related circulating microRNAs miR-29b-3p, miR-550a-3p, and miR-324-3p and their association to bone microstructure and histomorphometry
The assessment of bone quality and the prediction of fracture risk in idiopathic osteoporosis
(IOP) are complex prospects as bone mineral density (BMD) and bone turnover markers …
(IOP) are complex prospects as bone mineral density (BMD) and bone turnover markers …