The past two decades have seen remarkable progress in our understanding of the
multifactorial drivers of hippocampal aging and cognitive decline. Recent findings have also …

Knowledge of age sensitivity, the capacity of a behavioral test to reliably detect age-related
changes, has utility in the design of experiments to elucidate processes of normal aging. We …

Recent investigations into heterochronic parabiosis have unveiled robust rejuvenating
effects of young blood on aged tissues. However, the specific rejuvenating mechanisms …

Motor function in humans can be characterized with tests of locomotion, strength, balance,
and endurance. The aim of our project was to establish an analogous test battery to assess …

Aging is associated with impairments in learning, memory, and cognitive flexibility, as well
as a gradual decline in hippocampal neurogenesis. We investigated the performance of 6 …

In clinical organ transplantation, donor and recipient ages may differ substantially. Old donor
organs accumulate senescent cells that have the capacity to induce senescence in naïve …

Despite dedicated efforts to identify interventions to delay aging, most promising
interventions yielding dramatic life-span extension in animal models of aging are often …

As the population of people aged 60 or older continues to rise, it has become increasingly
important to understand the molecular basis underlying age-related cognitive decline. In …

Immune system hypersensitivity is believed to contribute to mental frailty in the elderly. Solid
evidence indicates NOD-like receptor pyrin domain containing-3 (NLRP3)-inflammasome …

Disruption of mitochondria axonal transport, essential for the maintenance of synaptic and
neuronal integrity and function, has been identified in neurodegenerative diseases. Whether …