Nucleoside diphosphate kinases (NDPK) are oligomeric proteins involved in the synthesis of
nucleoside triphosphates. Their tridimensional structure has been solved by X-ray …

Polyphosphate (polyP) is a conserved polymer of inorganic phosphate residues that can
reach thousands of moieties in length. PolyP has been implicated in cellular functions …

PRUNE is a member of the DHH (Asp-His-His) phosphoesterase protein superfamily of
molecules important for cell motility, and implicated in cancer progression. Here we …

Polyphosphate (polyP) is a linear chain of up to hundreds of inorganic phosphate residues
that is necessary for many physiological functions in all living organisms. In some bacteria …

Neuroblastoma is the most common extracranial solid tumor in childhood. Gain of
chromosome 17q material is found in> 60% of neuroblastoma tumors and is associated with …

Neuroblastoma is a childhood neurological tumor which affects hundreds of thousands of
children worldwide, and information about its prognosis can be pivotal for patients, their …

We describe here the molecular basis of the complex formation of PRUNE1 with the tumor
metastasis suppressors NME1 and NME2, two isoforms appertaining to the nucleoside …

Genetic modifications during development of paediatric groups 3 and 4 medulloblastoma
are responsible for their highly metastatic properties and poor patient survival rates …

The NM23/NME gene was identified as a metastasis suppressor. It's re-expression inhibited
cancer cell motility and suppressed metastasis, without effecting primary tumor size in …

Abstract Tripartite motif-containing 22 (TRIM22) has been documented to participate in
numerous cellular activities during human diseases. However, whether TRIM22 is involved …