Notch signaling in development, tissue homeostasis, and disease
C Siebel, U Lendahl - Physiological reviews, 2017 - journals.physiology.org
Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …
Epigenetics of glioblastoma multiforme: From molecular mechanisms to therapeutic approaches
MS Uddin, A Al Mamun, BS Alghamdi, D Tewari… - Seminars in cancer …, 2022 - Elsevier
Glioblastoma multiforme (GBM) is the most common form of brain cancer and one of the
most aggressive cancers found in humans. Most of the signs and symptoms of GBM can be …
most aggressive cancers found in humans. Most of the signs and symptoms of GBM can be …
Notch signaling: simplicity in design, versatility in function
Notch signaling is evolutionarily conserved and operates in many cell types and at various
stages during development. Notch signaling must therefore be able to generate appropriate …
stages during development. Notch signaling must therefore be able to generate appropriate …
[HTML][HTML] Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma
Both the perivascular niche (PVN) and the integration into multicellular networks by tumor
microtubes (TMs) have been associated with progression and resistance to therapies in …
microtubes (TMs) have been associated with progression and resistance to therapies in …
Notch signalling: a simple pathway becomes complex
SJ Bray - Nature reviews Molecular cell biology, 2006 - nature.com
A small number of signalling pathways are used iteratively to regulate cell fates, cell
proliferation and cell death in development. Notch is the receptor in one such pathway, and …
proliferation and cell death in development. Notch is the receptor in one such pathway, and …
A chemokine-driven positive feedback loop organizes lymphoid follicles
Lymphoid follicles are B-cell-rich compartments of lymphoid organs that function as sites of
B-cell antigen encounter and differentiation. CXC chemokine receptor-5 (CXCR5) is …
B-cell antigen encounter and differentiation. CXC chemokine receptor-5 (CXCR5) is …
Not (ch) just development: Notch signalling in the adult brain
The Notch pathway is often regarded as a developmental pathway, but components of Notch
signalling are expressed and active in the adult brain. With the advent of more sophisticated …
signalling are expressed and active in the adult brain. With the advent of more sophisticated …
[HTML][HTML] Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging
New neurons are generated in the adult hippocampus throughout life by neural
stem/progenitor cells (NSCs), and neurogenesis is a plastic process responsive to external …
stem/progenitor cells (NSCs), and neurogenesis is a plastic process responsive to external …
Notch signalling in vertebrate neural development
A Louvi, S Artavanis-Tsakonas - Nature Reviews Neuroscience, 2006 - nature.com
Signals through the Notch receptors are used throughout development to control cellular
fate choices. Loss-and gain-of-function studies revealed both the pleiotropic action of the …
fate choices. Loss-and gain-of-function studies revealed both the pleiotropic action of the …
[HTML][HTML] Notch signaling: from the outside in
Development makes reiterative use of a surprisingly small set of essential molecular signals:
the Wingless (Wg/Wnt), Hedgehog (Hh), Transforming Growth Factor-(TGF-), Receptor …
the Wingless (Wg/Wnt), Hedgehog (Hh), Transforming Growth Factor-(TGF-), Receptor …