Solid lipid nanoparticles for hydrophilic drugs

Y Mirchandani, VB Patravale, S Brijesh - Journal of Controlled Release, 2021 - Elsevier
Hydrophilic drugs are proficient therapeutic agents however, delivery of these drugs is a
difficult task. Hence, developing an efficient drug delivery system may require a …

Cell membrane coated nanocarriers-an efficient biomimetic platform for targeted therapy

P Dash, AM Piras, M Dash - Journal of controlled release, 2020 - Elsevier
Targeted therapy approaches have become the core of modern translational science and as
an intriguing field, it is the solution of the conventional drug delivery problems that were …

Preparation, characterization, and potential application of chitosan, chitosan derivatives, and chitosan metal nanoparticles in pharmaceutical drug delivery

TA Ahmed, BM Aljaeid - Drug design, development and therapy, 2016 - Taylor & Francis
Naturally occurring polymers, particularly of the polysaccharide type, have been used
pharmaceutically for the delivery of a wide variety of therapeutic agents. Chitosan, the …

Hydrogels for protein delivery

T Vermonden, R Censi, WE Hennink - Chemical reviews, 2012 - ACS Publications
Importantly, with the advent of hybridoma and recombinant DNA technologies, the limitations
associated with the extraction and purification of pharmaceutical proteins from animal …

Approaches for enhancing oral bioavailability of peptides and proteins

J Renukuntla, AD Vadlapudi, A Patel… - International journal of …, 2013 - Elsevier
Oral delivery of peptide and protein drugs faces immense challenge partially due to the
gastrointestinal (GI) environment. In spite of considerable efforts by industrial and academic …

Oral delivery of biologics for precision medicine

M Durán‐Lobato, Z Niu, MJ Alonso - Advanced Materials, 2020 - Wiley Online Library
The emerging field of precision medicine is rapidly growing, fostered by the advances in
genome mapping and molecular diagnosis. In general, the translation of these advances …

Recent advances in lipid nanoparticle formulations with solid matrix for oral drug delivery

S Das, A Chaudhury - Aaps Pharmscitech, 2011 - Springer
Lipid nanoparticles based on solid matrix have emerged as potential drug carriers to
improve gastrointestinal (GI) absorption and oral bioavailability of several drugs, especially …

Solid lipid nanoparticles for oral drug delivery: chitosan coating improves stability, controlled delivery, mucoadhesion and cellular uptake

Y Luo, Z Teng, Y Li, Q Wang - Carbohydrate polymers, 2015 - Elsevier
The poor stability of solid lipid nanoparticles (SLN) under acidic condition resulted in large
aggregation in gastric environment, limiting their application as oral delivery systems. In this …

Solid lipid nanoparticles for enhanced oral absorption: A review

E Salah, MM Abouelfetouh, Y Pan, D Chen… - colloids and surfaces B …, 2020 - Elsevier
Recent trends in nanoparticles-based oral therapy have led to a proliferation of studies to
enhance solubility, permeability and chemical stability of many drugs. One of the significant …

Solid lipid nanoparticles as a drug delivery system for peptides and proteins

AJ Almeida, E Souto - Advanced drug delivery reviews, 2007 - Elsevier
Solid lipid particulate systems such as solid lipid nanoparticles (SLN), lipid microparticles
(LM) and lipospheres have been sought as alternative carriers for therapeutic peptides …