First isolated and characterized in 1900 by Gulewitsch, carnosine (β-alanyl-L-hystidine) is a
dipeptide commonly present in mammalian tissue, and in particular in skeletal muscle cells; …

The predominant molecular symptom of aging is the accumulation of altered gene products.
Moreover, several conditions including protein, lipid or glucose oxidation disrupt redox …

Cyclodextrins (CDs) are cyclic oligomers of α-1, 4-linked D-glucopyranose. Due to their
unique structure, marked by a chiral and hydrophobic cavity, CDs have been extensively …

Carnosine (β-alanyl-l-histidine) is a natural dipeptide widely and abundantly distributed in
excitable tissues of several animal tissues. Although its physiological role has not been …

Carnosinases are Xaa-His dipeptidases that play diverse functions throughout all kingdoms
of life. Human isoforms of carnosinase (CN1 and CN2) under appropriate conditions …

[Frontiers in Bioscience 14, 376-397, January 1, 2009] 376 Vitagenes, dietary antioxidants and
neuroprotection in neurodegenerat Page 1 [Frontiers in Bioscience 14, 376-397, January 1 …

A thermodynamic study on the interactions of a naturally occurring dipeptide, l-carnosine,
and three transition metal cations, Cu 2+, Mn 2+ and Zn 2+, is reported. Their …

Reactive oxygen species are implicated in several human diseases, including
neurodegenerative disorders, cardiovascular dysfunction, inflammation, hereditary …

A series of copper (II) complexes with the formula [Cu2+ Hy (x) Car%] varying the molecular
weight (MW) of Hyaluronic acid (Hy, x= 200 or 700 kDa) conjugated with carnosine (Car) …

Formation of nitric oxide by astrocytes has been suggested to contribute, via impairment of
mitochondrial function, to the neurodegenerative process. Mitochondria under oxidative …