Metabolism and functions of copper in brain
IF Scheiber, JFB Mercer, R Dringen - Progress in neurobiology, 2014 - Elsevier
Copper is an important trace element that is required for essential enzymes. However, due
to its redox activity, copper can also lead to the generation of toxic reactive oxygen species …
to its redox activity, copper can also lead to the generation of toxic reactive oxygen species …
Copper metallochaperones
NJ Robinson, DR Winge - Annual review of biochemistry, 2010 - annualreviews.org
The current state of knowledge on how copper metallochaperones support the maturation of
cuproproteins is reviewed. Copper is needed within mitochondria to supply the CuA and …
cuproproteins is reviewed. Copper is needed within mitochondria to supply the CuA and …
The molecular and cellular basis of copper dysregulation and its relationship with human pathologies
MT Maung, A Carlson, M Olea‐Flores… - The FASEB …, 2021 - Wiley Online Library
Copper (Cu) is an essential micronutrient required for the activity of redox‐active enzymes
involved in critical metabolic reactions, signaling pathways, and biological functions …
involved in critical metabolic reactions, signaling pathways, and biological functions …
Affinity gradients drive copper to cellular destinations
L Banci, I Bertini, S Ciofi-Baffoni, T Kozyreva, K Zovo… - Nature, 2010 - nature.com
Copper is an essential trace element for eukaryotes and most prokaryotes. However,
intracellular free copper must be strictly limited because of its toxic side effects. Complex …
intracellular free copper must be strictly limited because of its toxic side effects. Complex …
Coordination chemistry of copper proteins: how nature handles a toxic cargo for essential function
JT Rubino, KJ Franz - Journal of inorganic biochemistry, 2012 - Elsevier
Biological copper is coordinated predominantly by just three ligand types: the side chains of
histidine, cysteine, and methionine, with of course some exceptions. The arrangement of …
histidine, cysteine, and methionine, with of course some exceptions. The arrangement of …
Copper, iron, and zinc ions homeostasis and their role in neurodegenerative disorders (metal uptake, transport, distribution and regulation)
H Kozlowski, A Janicka-Klos, J Brasun… - Coordination Chemistry …, 2009 - Elsevier
Metal ions, especially with high chemical activity (eg redox-active Cu and Fe) must be
carefully managed in biological systems. The “uncontrolled” activity, eg catalysis of Fenton …
carefully managed in biological systems. The “uncontrolled” activity, eg catalysis of Fenton …
ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function
M Darshi, VL Mendiola, MR Mackey, AN Murphy… - Journal of biological …, 2011 - ASBMB
The mitochondrial inner membrane (IM) serves as the site for ATP production by hosting the
oxidative phosphorylation complex machinery most notably on the crista membranes …
oxidative phosphorylation complex machinery most notably on the crista membranes …
MIA40 is an oxidoreductase that catalyzes oxidative protein folding in mitochondria
L Banci, I Bertini, C Cefaro, S Ciofi-Baffoni… - Nature structural & …, 2009 - nature.com
MIA40 has a key role in oxidative protein folding in the mitochondrial intermembrane space.
We present the solution structure of human MIA40 and its mechanism as a catalyst of …
We present the solution structure of human MIA40 and its mechanism as a catalyst of …
The Redox Environment in the Mitochondrial Intermembrane Space Is Maintained Separately from the Cytosol and Matrix∗
Redox control in the mitochondrion is essential for the proper functioning of this organelle.
Disruption of mitochondrial redox processes contributes to a host of human disorders …
Disruption of mitochondrial redox processes contributes to a host of human disorders …
Copper handling machinery of the brain
S Lutsenko, A Bhattacharjee, AL Hubbard - Metallomics, 2010 - academic.oup.com
Copper plays an indispensable role in the physiology of the human central nervous system
(CNS). As a cofactor of dopamine-β-hydroxylase, peptidyl-α-monooxygenase, superoxide …
(CNS). As a cofactor of dopamine-β-hydroxylase, peptidyl-α-monooxygenase, superoxide …