Amyotrophic lateral sclerosis (ALS) is the collective term for a fatal motoneuron disease of
different etiologies, with oxidative stress as a common molecular denominator of disease …

Objective: The fused in sarcoma/translated in liposarcoma (FUS/TLS) protein was recently
identified as a cause of familial amyotrophic lateral sclerosis (ALS), as well as a major …

Familial amyotrophic lateral sclerosis (FALS) is caused, in 20% of cases, by mutations in the
Cu/Zn superoxide dismutase gene (SOD1). Although motor neuron injury occurs through a …

Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by motor
neuron degeneration. Mutations in Cu, Zn-superoxide dismutase (SOD1) are responsible for …

Background Cytoplasmic inclusions of transactive response DNA binding protein of 43 kDa
(TDP-43) in neurons and astrocytes are a feature of some neurodegenerative diseases …

Background Progranulin is a secreted high molecular weight growth factor bearing seven
and one half copies of the cysteine-rich granulin-epithelin motif. While inappropriate over …

Spinal muscular atrophy (SMA) is a neuromuscular disease characterized by loss of lower
motor neurons, which leads to proximal muscle weakness and atrophy. SMA is caused by …

Alpha-motoneurons appear to be exceedingly affected in neurodegenerative diseases such
as amyotrophic lateral sclerosis (ALS). Morphological and physiological degeneration of this …

Motor neuron diseases are neurodegenerative diseases that predominantly affect the
neuromuscular system. To date, there are no valid therapeutic treatments for such diseases …

In a subgroup of patients with amyotrophic lateral sclerosis (ALS)/Frontotemporal dementia
(FTD), the (G4C2)-RNA repeat expansion from C9orf72 chromosome binds to the Ran …