Metabolites from marine fungi have hogged the limelight in drug discovery because of their
promise as therapeutic agents. A number of metabolites related to marine fungi have been …

Isothermal titration calorimetry (ITC) is a biophysical technique for measuring the formation
and dissociation of molecular complexes and has become an invaluable tool in many …

Covering: 1980 to 2011 Major groove recognition of DNA by proteins utilizes the variation in
hydrogen bond donor/acceptor content that makes DNA base-pairs distinguishable from one …

Small molecule ligands that could stabilize G-quadruplex structure formed at the promoter
region of human c-myc oncogene will regulate its expression in cancer cells. Flavonoids, a …

Piperine, a naturally occurring alkaloid, is well known as anti-oxidant, anti-mutagenic, anti-
tumor and anti-proliferative agent. Piperine exerts such pharmacological activities by …

Quadruplex nucleic acids are secondary structures that may form in sequences containing
guanine repeats.[1] These structures are strongly suspected to interfere with the transfer and …

A mixed parallel scheme that combines message passing interface (MPI) and multithreading
was implemented in the AutoDock Vina molecular docking program. The resulting program …

Synthesis of a novel perylene− neomycin conjugate (3) and the properties of its binding to
human telomeric G-quadruplex DNA, 5′-d [AG3 (T2AG3) 3](4), are reported. Various …

A dimeric neomycin− neomycin conjugate 3 with a flexible linker, 2, 2′-(ethylenedioxy) bis
(ethylamine), has been synthesized and characterized. Dimer 3 can selectively bind to AT …

Recognition of nucleic acids is important for our understanding of nucleic acid structure as
well as for our understanding of nucleic acid–protein interactions. In addition to the direct …