Triple-negative breast cancer (TNBC) is a highly lethal malignancy, and its clinical
management encounters severe challenges due to its high metastatic propensity and the …

Drug discovery focusing on NO mimetics has been hamstrung due to its unconventional
nature. Central to these challenges is the fact that direct measurement of molecular NO in …

Herein, the development of a visible‐light‐induced catalytic system to achieve the
decarboxylative acylation of pyridine N‐oxides with α‐oxocarboxylic acids, at room …

The development of novel therapeutic strategies for combating Alzheimer's disease (AD) is
challenging but imperative. Multifunctional nanoparticles are promising tools for regulating …

NiCl2 (PMe3) 2-catalyzed reaction of allyl alcohols with silylzinc reagents, including
PhMe2SiZnCl, Ph2MeSiZnCl, and Ph3SiZnCl, was performed, achieving allylsilanes in high …

As our ongoing work on lathyrane diterpenoid derivatization, three series of lathyrane
diterpenoid derivatives were designed and synthesized based combination principles …

Aim: Co-metabolism between a human host and the gastrointestinal microbiota generates
many small phenolic molecules such as 3-hydroxy-3-(3-hydroxyphenyl) propanoic acid (3, 3 …

Furoxans are potentially useful heteroaromatic units in pharmaceuticals and agrichemicals.
However, the applications for furoxan-based compounds have been hampered due to the …

An efficient synthesis method was developed for furoxan/1, 2, 4-triazole hybrids 5a–k from
methyl 5-(halomethyl)-1-aryl-1H-1, 2, 4-triazole-3-carboxylates 1 through two-steps reaction …

Abstract Development of hybrid drug candidates is well known strategy for designing
antitumor agents. Herein, a novel class of nitric oxide donating cucurbitacin inspired estrone …