As the population ages due to demographic trends and gains in life expectancy, the
incidence and prevalence of dementia increases, and the need to understand the etiology …

Cerebrovascular reactivity is the change in cerebral blood flow in response to a vasodilatory
or vasoconstrictive stimulus. Measuring variations of cerebrovascular reactivity between …

There is accumulating evidence suggesting that changes in brain perfusion are present long
before the clinical symptoms of Alzheimer's disease (AD), perhaps even before amyloid-β …

Abstract Study Objectives: Emerging evidence suggests a role for sleep in contributing to the
progression of Alzheimer disease (AD). Slow wave sleep (SWS) is the stage during which …

The vascular hypothesis of Alzheimer's disease (VHAD) was proposed 24 years ago from
observations made in our laboratory using aging rats subjected to chronic brain …

Considerable information is currently available from neuroimaging, pathological, and
population-based prospective studies showing that vascular risk factors are independently …

Vascular smooth muscle cells (VSMCs) are the key moderators of cerebrovascular dynamics
in response to the brain's oxygen and nutrient demands. Crucially, VSMCs may provide a …

Background: The incidence of dementia is projected to rise over the coming decades, but
with no sensitive diagnostic tests available. Vascular pathology precedes the deposition of …

Stimulation of cerebral vasculature using hypercapnia has been widely used to study
cerebral vascular reactivity (CVR), which can be expressed as the quantitative change in …

There is growing evidence that cerebrovascular reactivity to carbon dioxide (CVR CO 2) is
impaired in Alzheimer's disease (AD). Preclinical and animal studies suggest chronic …