The Wnt pathway is central to a host of developmental and disease-related processes. The
remarkable conservation of this intercellular signaling cascade throughout metazoan …

In the mammalian liver, hepatocytes exhibit diverse metabolic and functional profiles based
on their location within the liver lobule. However, it is unclear whether this spatial variation …

Simple Summary Cancer is caused by a breakdown of cell-to-cell communication, which
results in the unrestricted expansion of cells within a tissue. In many cases, tumor growth is …

WNT/β-catenin signaling controls gene expression across biological contexts from
development and stem cell homeostasis to diseases including cancer. How β-catenin is …

Hepatocellular carcinoma (HCC) takes the predominant malignancy of hepatocytes with
bleak outcomes owing to high heterogeneity among patients. Personalized treatments …

Cell proliferation is tightly controlled by inhibitors that block cell cycle progression until
growth signals relieve this inhibition, allowing cells to divide. In several tissues, including the …

Upon WNT/β-catenin pathway activation, stabilized β-catenin travels to the nucleus where it
associates with the TCF/LEF transcription factors, constitutively bound to genomic Wnt …

Canonical Wnt/β-catenin signaling is an established regulator of cellular state and its critical
contributions to tumor initiation, malignant tumor progression and metastasis formation have …

Chinese ponies are endemic to the mountainous areas of southwestern China and were first
reported in the archaeological record at the Royal Tomb of Zhongshan King, Mancheng …

Wnt signaling orchestrates gene expression via its effector, β-catenin. However, it is
unknown whether β-catenin binds its target genomic regions simultaneously and how this …