Protein phosphatase 2A (PP2A) comprises a family of serine/threonine phosphatases,
minimally containing a well conserved catalytic subunit, the activity of which is highly …

Tumor formation results from alterations in the control of normal cell proliferation. To further
our understanding of the molecular mechanisms underlying the deregulation of cell …

Sister chromatid cohesion, mediated by a complex called cohesin, is crucial—particularly at
centromeres—for proper chromosome segregation in mitosis and meiosis. In animal mitotic …

The retinoblastoma protein (p110RB) interacts with many cellular proteins in complexes
potentially important for its growth-suppressing function. We have developed and used an …

The PR65/A subunit of protein phosphatase 2A serves as a scaffolding molecule to
coordinate the assembly of the catalytic subunit and a variable regulatory B subunit …

Data generated in the new National Cancer Institute drug evaluation program, which is
based on inhibition of cell growth in 60 human tumor cell lines, were used to compare new …

Segregation of homologous maternal and paternal centromeres to opposite poles during
meiosis I depends on post-replicative crossing over between homologous non-sister …

The widespread reorganization of cellular architecture in mitosis is achieved through
extensive protein phosphorylation, driven by the coordinated activation of a mitotic kinase …

The end of the RNA polymerase II (Pol II) transcription cycle is strictly regulated to prevent
interference between neighbouring genes and to safeguard transcriptome integrity. The …

Protein phosphatase 1 (PP1) is a serine/threonine protein phosphatase that is essential in
regulating diverse cellular processes. Here we report the crystal structure of the catalytic …