Red blood cell metabolism in vivo and in vitro
Red blood cells (RBC) are the most abundant cell in the human body, with a central role in
oxygen transport and its delivery to tissues. However, omics technologies recently revealed …
oxygen transport and its delivery to tissues. However, omics technologies recently revealed …
Red blood cell storage: from genome to exposome towards personalized transfusion medicine
A D'Alessandro, EA Hod - Transfusion Medicine Reviews, 2023 - Elsevier
Over the last decade, the introduction of omics technologies–especially high-throughput
genomics and metabolomics–has contributed significantly to our understanding of the role of …
genomics and metabolomics–has contributed significantly to our understanding of the role of …
A phase I/Ib trial and biological correlate analysis of neoadjuvant SBRT with single-dose durvalumab in HPV-unrelated locally advanced HNSCC
LB Darragh, MM Knitz, J Hu, ET Clambey, J Backus… - Nature Cancer, 2022 - nature.com
Five-year survival for human papilloma virus-unrelated head and neck squamous cell
carcinomas remain below 50%. We assessed the safety of administering combination …
carcinomas remain below 50%. We assessed the safety of administering combination …
Assessment of stored red blood cells through lab-on-a-chip technologies for precision transfusion medicine
Z Isiksacan, A D'Alessandro, SM Wolf… - Proceedings of the …, 2023 - National Acad Sciences
Transfusion of red blood cells (RBCs) is one of the most valuable and widespread
treatments in modern medicine. Lifesaving RBC transfusions are facilitated by the cold …
treatments in modern medicine. Lifesaving RBC transfusions are facilitated by the cold …
Antioxidant Activity of Quercetin in a H2O2-Induced Oxidative Stress Model in Red Blood Cells: Functional Role of Band 3 Protein
A Remigante, S Spinelli, E Straface… - International journal of …, 2022 - mdpi.com
During their lifespan, red blood cells (RBCs) are exposed to a large number of stressors and
are therefore considered as a suitable model to investigate cell response to oxidative stress …
are therefore considered as a suitable model to investigate cell response to oxidative stress …
High-throughput metabolomics platform for the rapid data-driven development of novel additive solutions for blood storage
T Nemkov, T Yoshida, M Nikulina… - Frontiers in …, 2022 - frontiersin.org
Red blood cell transfusion is a life-saving intervention, and storage is a logistic necessity to
make~ 110 million units available for transfusion every year worldwide. However, storage in …
make~ 110 million units available for transfusion every year worldwide. However, storage in …
Metabolic reprogramming under hypoxic storage preserves faster oxygen unloading from stored red blood cells
J Rabcuka, S Blonski, A Meli… - Blood …, 2022 - ashpublications.org
Stored red blood cells (RBCs) incur biochemical and morphological changes, collectively
termed the storage lesion. Functionally, the storage lesion manifests as slower oxygen …
termed the storage lesion. Functionally, the storage lesion manifests as slower oxygen …
Sphingosine 1-phosphate has a negative effect on RBC storage quality
A Hay, T Nemkov, F Gamboni… - Blood …, 2023 - ashpublications.org
Blood storage promotes the rapid depletion of red blood cell (RBC) high-energy adenosine
triphosphate (ATP) and 2, 3-diphosphoglycerate (DPG), which are critical regulators of …
triphosphate (ATP) and 2, 3-diphosphoglycerate (DPG), which are critical regulators of …
Genome-wide metabolite quantitative trait loci analysis (mQTL) in red blood cells from volunteer blood donors
A Moore, MP Busch, K Dziewulska, RO Francis… - Journal of Biological …, 2022 - ASBMB
The red blood cell (RBC)-Omics study, part of the larger NHLBI-funded Recipient
Epidemiology and Donor Evaluation Study (REDS-III), aims to understand the genetic …
Epidemiology and Donor Evaluation Study (REDS-III), aims to understand the genetic …
Cross-talk between red blood cells and plasma influences blood flow and omics phenotypes in severe COVID-19
SM Recktenwald, G Simionato, MGM Lopes… - Elife, 2022 - elifesciences.org
Abstract Coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2) and can affect multiple organs, among which is the …
Syndrome Coronavirus 2 (SARS-CoV-2) and can affect multiple organs, among which is the …