Proteases play critical roles in virtually all biological processes, including proliferation, cell
death and survival, protein turnover, and migration. However, when dysregulated, these …

Proteases are an evolutionarily conserved family of enzymes that degrade peptide bonds
and have been implicated in several common gastrointestinal (GI) diseases. Although …

Ulcerative colitis (UC) is driven by disruptions in host–microbiota homoeostasis, but current
treatments exclusively target host inflammatory pathways. To understand how host …

Up to 20% of people worldwide develop gastrointestinal symptoms following a meal, leading
to decreased quality of life, substantial morbidity and high medical costs. Although the …

Background & Aims Altered gut microbiota composition and function have been associated
with inflammatory bowel diseases, including ulcerative colitis (UC), but the causality and …

Intestinal proteases mediate digestion and immune signalling, while increased gut
proteolytic activity disrupts the intestinal barrier and generates visceral hypersensitivity …

Inflammatory Bowel Diseases (IBD) are chronic inflammatory disorders, where epithelial
defects drive, at least in part, some of the pathology. We reconstituted human intestinal …

Microbe-host interactions are generally homeostatic, but when dysfunctional, they can incite
food sensitivities and chronic diseases. Celiac disease (CeD) is a food sensitivity …

Serine proteases are extensively known to play key roles in many physiological processes.
However, their dysregulation is often associated to several diseases including inflammatory …

Objective The intestinal lumen contains several proteases. Our aim was to determine the
role of faecal proteases in mediating barrier dysfunction and symptoms in IBS. Design 39 …