Catalyzed by endothelial nitric oxide (NO) synthase (eNOS) activity, NO is a gaseous
signaling molecule maintaining endothelial and cardiovascular homeostasis. Principally, NO …

Ocular hypertension in glaucoma develops due to age-related cellular dysfunction in the
conventional outflow tract, resulting in increased resistance to aqueous humor outflow. Two …

The aqueous humor (AH) outflow pathways definition is still matter of intense debate. To
date, the differentiation between conventional (trabecular meshwork) and unconventional …

The trabecular meshwork (TM) plays an important role in high‐tension glaucomas. Indeed,
the TM is a true organ, through which the aqueous humor flows from the anterior chamber to …

Polymorphisms in the CAV1/2 genes that encode signature proteins of caveolae are
associated with glaucoma, the second leading cause of blindness worldwide, and with its …

The aim of this article is to discuss how physiology and anatomical background affect the
effectiveness of implant‐dependent microinvasive glaucoma surgery (MIGS). First, we …

In a healthy eye, the aqueous humour (AH) flows via the ciliary body and trabecular
meshwork into the collector channels, which carry it to the episcleral veins. In glaucoma, a …

In a series of previous publications we have proposed a framework for conceptualizing the
optic nerve head (ONH) as a biomechanical structure. That framework proposes important …

Rare missense and nonsense variants in the Angiopoietin-like 7 (ANGPTL7) gene confer
protection from primary open-angle glaucoma (POAG), though the functional mechanism …

Microinvasive glaucoma surgery has gained popularity over the past decade. It can be
performed using three different mechanisms. In the present review, we focused on …