Dendritic structural plasticity and neuropsychiatric disease
MP Forrest, E Parnell, P Penzes - Nature Reviews Neuroscience, 2018 - nature.com
The structure of neuronal circuits that subserve cognitive functions in the brain is shaped
and refined throughout development and into adulthood. Evidence from human and animal …
and refined throughout development and into adulthood. Evidence from human and animal …
[HTML][HTML] Recurrent de novo mutations in neurodevelopmental disorders: properties and clinical implications
Next-generation sequencing (NGS) is now more accessible to clinicians and researchers.
As a result, our understanding of the genetics of neurodevelopmental disorders (NDDs) has …
As a result, our understanding of the genetics of neurodevelopmental disorders (NDDs) has …
[HTML][HTML] Pharmacogenomics of GPCR drug targets
Natural genetic variation in the human genome is a cause of individual differences in
responses to medications and is an underappreciated burden on public health. Although …
responses to medications and is an underappreciated burden on public health. Although …
[HTML][HTML] Comparative genetic architectures of schizophrenia in East Asian and European populations
Schizophrenia is a debilitating psychiatric disorder with approximately 1% lifetime risk
globally. Large-scale schizophrenia genetic studies have reported primarily on European …
globally. Large-scale schizophrenia genetic studies have reported primarily on European …
[HTML][HTML] Large-scale targeted sequencing identifies risk genes for neurodevelopmental disorders
Most genes associated with neurodevelopmental disorders (NDDs) were identified with an
excess of de novo mutations (DNMs) but the significance in case–control mutation burden …
excess of de novo mutations (DNMs) but the significance in case–control mutation burden …
[HTML][HTML] Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases
Gene-disruptive mutations contribute to the biology of neurodevelopmental disorders
(NDDs), but most of the related pathogenic genes are not known. We sequenced 208 …
(NDDs), but most of the related pathogenic genes are not known. We sequenced 208 …
RMVar: an updated database of functional variants involved in RNA modifications
X Luo, H Li, J Liang, Q Zhao, Y Xie, J Ren… - Nucleic acids …, 2021 - academic.oup.com
Distinguishing the few disease-related variants from a massive number of passenger
variants is a major challenge. Variants affecting RNA modifications that play critical roles in …
variants is a major challenge. Variants affecting RNA modifications that play critical roles in …
Transcriptome and epigenome landscape of human cortical development modeled in organoids
INTRODUCTION The human cerebral cortex has undergone an extraordinary increase in
size and complexity during mammalian evolution. Cortical cell lineages are specified in the …
size and complexity during mammalian evolution. Cortical cell lineages are specified in the …
POSTAR3: an updated platform for exploring post-transcriptional regulation coordinated by RNA-binding proteins
W Zhao, S Zhang, Y Zhu, X Xi, P Bao, Z Ma… - Nucleic Acids …, 2022 - academic.oup.com
RNA-binding proteins (RBPs) play key roles in post-transcriptional regulation. Accurate
identification of RBP binding sites in multiple cell lines and tissue types from diverse species …
identification of RBP binding sites in multiple cell lines and tissue types from diverse species …
[HTML][HTML] Neurodevelopmental disease genes implicated by de novo mutation and copy number variation morbidity
We combined de novo mutation (DNM) data from 10,927 individuals with developmental
delay and autism to identify 253 candidate neurodevelopmental disease genes with an …
delay and autism to identify 253 candidate neurodevelopmental disease genes with an …