The evolving concept that cancer stem cells (CSCs) are the driving element in cancer
development, evolution and heterogeneity, has overridden the previous model of a tumor …

Breast cancer displays disparities in mortality between African Americans and Caucasian
Americans. However, the exact molecular mechanisms remain elusive. Here, we identify …

Background The TGF-β pathway plays critical roles in numerous malignancies.
Nevertheless, its potential role in prognosis prediction and regulating tumour …

Inhibin subunit beta A (INHBA) is a member of the transforming growth factor-beta (TGF-β)
superfamily that plays a fundamental role in various cancers. However, a systematic …

Objective: Ovarian cancer is one of the most common and lethal cancer types in women. The
molecular mechanism of ovarian cancer progression is still unclear. Results: Here, we first …

Background: Inhibitors of DNA-binding (ID) proteins are important regulators of cell
proliferation and differentiation. The aim of this study was to evaluated the role of ID proteins …

Invasive lobular breast carcinoma (ILC) is characterized by proliferative indolence and long-
term latency relapses. This study aimed to identify how disseminating ILC cells control the …

Background Autoimmune uveitis (AU) is the most common ophthalmic autoimmune disease
(AD) and is characterized by a complex etiology, high morbidity, and high rate of blindness …

Cancer prevention has a profound impact on cancer-associated mortality and morbidity. We
previously identified TGFβ signaling as a candidate regulator of mammary epithelial cells …

A family of inhibitors of cell differentiation or DNA-binding proteins, known as ID proteins
(ID1-4), function as mighty transcription factors in various cellular processes, such as …