This review provides an update of the genetic content, phylogeny and evolution of the family
Adenoviridae. An appraisal of the condition of adenovirus genomics highlights the need to …

Over the past three years, there have been several interesting advances in our
understanding of the functions encoded by the adenovirus (Ad) E4 gene. In this review, I …

The 9ORF1 gene encodes an adenovirus E4 region oncoprotein that requires a C-terminal
region for transforming activity. Screening a λgt11 cDNA expression library with a 9ORF1 …

The oncoproteins of small DNA tumor viruses promote tumorigenesis by complexing with
cellular factors intimately involved in the control of cell proliferation. The major oncogenic …

ABSTRACT A general theme that has emerged from studies of DNA tumor viruses is that
otherwise unrelated oncoproteins encoded by these viruses often target the same important …

The development of human cancers is frequently associated with a failure of epithelial cells
to form tight junctions and to establish proper apicobasal polarity. Interestingly, the …

ABSTRACT dUTPase is a ubiquitous and essential enzyme responsible for regulating
cellular levels of dUTP. The dut gene exists as single, tandemly duplicated, and tandemly …

Adenovirus type 5 E4 open reading frame 4 (E4orf4) protein has been previously shown to
counteract transactivation of the junB and c-fos genes by cyclic AMP plus E1A protein and to …

Previous studies by our group showed that infection of human and rodent cells by human
adenovirus type 5 (Ad5) results in the induction of p53-independent apoptosis and cell …

We have recently demonstrated that Epstein-Barr virus (EBV)-encoded deoxyuridine
triphosphate nucleotidohydrolase (dUTPase) modulates innate immunity in human primary …