This narrative review represents an output from the International Association for the Study of
Pain's global task force on the use of cannabis, cannabinoids, and cannabis-based …

The endocannabinoid system (ECS) is a widespread neuromodulatory system that plays
important roles in central nervous system development, synaptic plasticity, and the response …

Apart from having been used and misused for at least four millennia for, among others,
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …

Endocannabinoids (eCBs) are retrograde neuromodulators with important functions in a
wide range of physiological processes, but their in vivo dynamics remain largely …

Endocannabinoids are key modulators of synaptic function. By activating cannabinoid
receptors expressed in the central nervous system, these lipid messengers can regulate …

Cannabis has been used for centuries to treat seizures. Recent anecdotal reports,
accumulating animal model data, and mechanistic insights have raised interest in cannabis …

▪ Abstract Synaptic transmission is a dynamic process. Postsynaptic responses wax and
wane as presynaptic activity evolves. This prominent characteristic of chemical synaptic …

Endocannabinoids (eCBs) exert major control over neuronal activity by activating
cannabinoid receptors (CBRs). The functionality of the eCB system is primarily ascribed to …

LTP and LTD, the long-term potentiation and depression of excitatory synaptic transmission,
are widespread phenomena expressed at possibly every excitatory synapse in the …

Despite being regarded as a hippie science for decades, cannabinoid research has finally
found its well-deserved position in mainstream neuroscience. A series of groundbreaking …