Exogenous and endogenous dendritic cell-derived exosomes: Lessons learned for immunotherapy and disease pathogenesis

M Elashiry, R Elsayed, CW Cutler - Cells, 2021 - mdpi.com
Immune therapeutic exosomes, derived exogenously from dendritic cells (DCs), the
'directors' of the immune response, are receiving favorable safety and tolerance profiles in …

Cargoes of exosomes function as potential biomarkers for Mycobacterium tuberculosis infection

N Wang, Y Yao, Y Qian, D Qiu, H Cao, H Xiang… - Frontiers in …, 2023 - frontiersin.org
Exosomes as double-membrane vesicles contain various contents of lipids, proteins,
mRNAs and non-coding RNAs, and involve in multiple physiological processes, for instance …

Diagnosis of genitourinary tuberculosis: detection of mycobacterial lipoarabinomannan and MPT-64 biomarkers within urine extracellular vesicles by nano-based …

E Kamra, T Prasad, A Rais, B Dahiya, A Sheoran… - Scientific Reports, 2023 - nature.com
We detected a cocktail of Mycobacterium tuberculosis lipoarabinomannan (LAM) and MPT-
64 biomarkers within urine extracellular vesicles (EVs) of genitourinary TB (GUTB) patients …

Emerging role of exosomes in tuberculosis: from immunity regulations to vaccine and immunotherapy

YF Sun, J Pi, JF Xu - Frontiers in Immunology, 2021 - frontiersin.org
Exosomes are cell-derived nanovesicles carrying protein, lipid, and nucleic acid for
secreting cells, and act as significant signal transport vectors for cell-cell communication and …

Extracellular vesicles in mycobacteria and tuberculosis

C Mehaffy, JM Ryan, NA Kruh-Garcia… - Frontiers in Cellular and …, 2022 - frontiersin.org
Tuberculosis (TB) remains a public health issue causing millions of infections every year. Of
these, about 15% ultimately result in death. Efforts to control TB include development of new …

Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis

S Parveen, J Shen, S Lun, L Zhao, J Alt… - Nature …, 2023 - nature.com
As one of the most successful human pathogens, Mycobacterium tuberculosis (Mtb) has
evolved a diverse array of determinants to subvert host immunity and alter host metabolic …

[HTML][HTML] Extracellular vesicles as carriers of mRNA: Opportunities and challenges in diagnosis and treatment

RD Kirian, D Steinman, CM Jewell, HC Zierden - Theranostics, 2024 - ncbi.nlm.nih.gov
Extracellular vesicles (EVs) are produced by all cells in the body. These biological
nanoparticles facilitate cellular communication through the transport of diverse cargoes …

New biomarker in Chagas disease: extracellular vesicles isolated from peripheral blood in chronic Chagas disease patients modulate the human immune response

RP Madeira, LM Dal'Mas Romera… - Journal of …, 2021 - Wiley Online Library
Chagas disease, a neglected tropical disease (NTD) caused by the flagellated protozoan
Trypanosoma cruzi (T. cruzi), is a major public health problem. It was initially restricted to …

Proteomics of blood extracellular vesicles in inflammatory respiratory diseases for biomarker discovery and new insights into pathophysiology

T Kawasaki, Y Takeda, A Kumanogoh - Inflammation and Regeneration, 2024 - Springer
Background Inflammatory respiratory diseases, such as interstitial lung disease (ILD),
bronchial asthma (BA), chronic obstructive pulmonary disease (COPD), and respiratory …

Advances in diagnostic tools for respiratory tract infections: from tuberculosis to COVID-19–changing paradigms?

Z Stojanovic, F Gonçalves-Carvalho… - ERJ Open …, 2022 - Eur Respiratory Soc
Respiratory tract infections (RTIs) are one of the most common reasons for seeking
healthcare, but are amongst the most challenging diseases in terms of clinical decision …