Collinear regulation of Hox genes in space and time has been an outstanding question ever
since the initial work of Ed Lewis in 1978. Here we discuss recent advances in our …

Our understanding of the molecular events underpinning the development of mammalian
organ systems has been increasing rapidly in recent years. With the advent of new and …

The mammalian HoxD cluster lies between two topologically associating domains (TADs)
matching distinct enhancer-rich regulatory landscapes. During limb development, the …

Breast cancer develops in the mammary glands during mammalian adulthood and is
considered the second most common type of human carcinoma and the most incident and …

Developmental genes can have complex cis-regulatory regions with multiple enhancers.
Early work revealed remarkable modularity of enhancers, whereby distinct DNA regions …

How organs originate and evolve is a question fundamental to understanding the evolution
of complex multicellular life forms. Vertebrates have a relatively standard body plan with …

The current paradigm in the field of gene regulation postulates that regulatory information for
generating gene expression is organized into modules (enhancers), each containing the …

The HoxD gene cluster is critical for proper limb formation in tetrapods. In the emerging limb
buds, different subgroups of Hoxd genes respond first to a proximal regulatory signal, then to …

The coordinated expression of the Hox gene family encoding transcription factors is critical
for proper embryonic development and patterning. Major efforts have thus been dedicated to …

Mammalian Hox gene clusters contain a range of CTCF binding sites. In addition to their
importance in organizing a TAD border, which isolates the most posterior genes from the …