Immunotherapy has revolutionized cancer treatment and substantially improved patient
outcome with regard to multiple tumour types. However, most patients still do not benefit …

Genome instability is a hallmark of cancer, and DNA replication is the most vulnerable
cellular process that can lead to it. Any condition leading to high levels of DNA damage will …

The discovery of Toll-like receptors (TLRs) as components that recognize conserved
structures in pathogens has greatly advanced understanding of how the body senses …

Inflammatory responses play decisive roles at different stages of tumor development,
including initiation, promotion, malignant conversion, invasion, and metastasis. Inflammation …

The mechanisms by which tumor microenvironments modulate nucleic acid–mediated
innate immunity remain unknown. Here we identify the receptor TIM-3 as key in …

Foreign nucleic acids, the signature of invading viruses and certain bacteria, are sensed
intracellularly. The nucleic acid-specific Toll-like receptors (TLRs) detect and signal within …

Many cancer-associated somatic copy number alterations (SCNAs) are known. Currently,
one of the challenges is to identify the molecular downstream effects of these variants …

The mammalian innate immune system detects the presence of microbial infection through
germ line-encoded pattern recognition receptors (PRRs). Toll-like receptors, retinoic acid …

Insulin resistance is common in individuals with obesity or type 2 diabetes (T2D), in which
circulating insulin levels are frequently increased. Recent epidemiological and clinical …

DNA repair pathways can enable tumour cells to survive DNA damage that is induced by
chemotherapeutic treatments; therefore, inhibitors of specific DNA repair pathways might …