The liver is a central organ in the human body, coordinating several key metabolic roles. The
structure of the liver which consists of the distinctive arrangement of hepatocytes, hepatic …

Liver fibrosis is the final common pathway of chronic or iterative liver damage. Advanced
chronic fibrosis is described as cirrhosis with a loss of architecture and attendant functional …

The liver is a large highly vascularized organ with a central function in metabolic
homeostasis, detoxification, and immunity. Due to its roles, the liver is frequently exposed to …

The liver performs a multitude of bodily functions, whilst retaining the ability to regenerate
damaged tissue. In this review, we discuss sex steroid biology, regulation of mammalian …

Liver fibrosis is defined as excessive extracellular matrix deposition and is based on
complex interactions between matrix-producing hepatic stellate cells and an abundance of …

Background & Aims Macrophages play vital roles in chronic liver injury, and have been
tested as a tool for cytotherapy in liver fibrosis. However, macrophages possess ontogenic …

The liver plays a major role in iron homeostasis; thus, in patients with chronic liver disease,
iron regulation may be disturbed. Higher iron levels are present not only in patients with …

The inflammatory response to chronic injury affects tissue regeneration and has become an
important factor influencing the prognosis of patients. In previous stem cell treatments, it was …

Autophagy is a lysosomal degradation pathway of cellular components that displays
antiinflammatory properties in macrophages. Macrophages are critically involved in chronic …

Fibrosis is a basic connective tissue lesion defined by the increase in the fibrillar
extracellular matrix (ECM) components in tissue or organ. Matrix metalloproteinases (MMPs) …