Melatonin, the circadian multioscillator system and health: the need for detailed analyses of peripheral melatonin signaling

R Hardeland, JA Madrid, DX Tan… - Journal of pineal …, 2012 - Wiley Online Library
Evidence is accumulating regarding the importance of circadian core oscillators, several
associated factors, and melatonin signaling in the maintenance of health. Dysfunction of …

The chronobiology, etiology and pathophysiology of obesity

M Garaulet, JM Ordovas, JA Madrid - International journal of Obesity, 2010 - nature.com
The effect of CD on human health is an emerging issue. Many records link CD with diseases
such as cancer, cardiovascular, cognitive impairment and obesity, all of them conducive to …

Minireview: entrainment of the suprachiasmatic clockwork in diurnal and nocturnal mammals

E Challet - Endocrinology, 2007 - academic.oup.com
Daily rhythmicity, including timing of wakefulness and hormone secretion, is mainly
controlled by a master clock located in the suprachiasmatic nucleus (SCN) of the …

Circadian rhythm of wrist temperature in normal-living subjects: A candidate of new index of the circadian system

JA Sarabia, MA Rol, P Mendiola, JA Madrid - Physiology & behavior, 2008 - Elsevier
Most circadian rhythms are under the control of a major pacemaker located in the
hypothalamic suprachiasmatic nucleus. Some of these rhythms, called marker rhythms …

Circadian rhythms and depression: human psychopathology and animal models

N Kronfeld-Schor, H Einat - Neuropharmacology, 2012 - Elsevier
Most organisms (including humans) developed daily rhythms in almost every aspect of their
body. It is not surprising that rhythms are also related to affect in health and disease. In the …

The validity, reliability, and utility of the iButton® for measurement of body temperature circadian rhythms in sleep/wake research

MJ Hasselberg, J McMahon, K Parker - Sleep medicine, 2013 - Elsevier
OBJECTIVE: Changes in core body temperature due to heat transfer through the skin have a
major influence on sleep regulation. Traditional measures of skin temperature are often …

Disruption of circadian rhythms and delirium, sleep impairment and sepsis in critically ill patients. Potential therapeutic implications for increased light-dark contrast …

CJ Madrid-Navarro, R Sanchez-Galvez… - Current …, 2015 - ingentaconnect.com
The confinement of critically ill patients in intensive care units (ICU) imposes environmental
constancy throughout both day and night (continuous light, noise, caring activities …

Diseases in pet degus: a retrospective study in 300 animals

V Jekl, K Hauptman, Z Knotek - Journal of Small Animal …, 2011 - Wiley Online Library
Introduction: Degus are commonly used as laboratory animals; however, over the past few
years, they have become increasingly popular as pets. Objectives: The aim of this article …

Melatonin beyond its classical functions

R Hardeland, B Poeggeler - The Open Physiology Journal, 2008 - benthamopen.com
The perception of melatonin as a mediator of darkness, formed in a circadian fashion,
circulating in subnanomolar concentrations, and removed as 6-sulfatoxymelatonin, reflects …

Age-related brain pathology in Octodon degu: blood vessel, white matter and Alzheimer-like pathology

T van Groen, I Kadish, N Popović, M Popović… - Neurobiology of …, 2011 - Elsevier
Recently it has been shown that over 3-year-old wild-type South American rodents, Octodon
degus, the “common degu” or degu, of their own accord develop Alzheimer's disease …