Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases,
characterized by impaired cognitive function due to progressive loss of neurons in the brain …

Abstract l-Tryptophan (Trp) metabolism through the kynurenine pathway (KP) is involved in
the regulation of immunity, neuronal function and intestinal homeostasis. Imbalances in Trp …

Inflammation aims to restore tissue homeostasis after injury or infection. Age-related decline
of tissue homeostasis causes a physiological low-grade chronic inflammatory phenotype …

Neuroinflammation commences decades before Alzheimer's disease (AD) clinical onset and
represents one of the earliest pathomechanistic alterations throughout the AD continuum …

Recent advances highlight a pivotal role for cellular metabolism in programming immune
responses. Here, we demonstrate that cell-autonomous generation of nicotinamide adenine …

The production of soluble amyloid-β oligomers (AβOs) and the activation of inflammation are
two important early steps in the pathogenesis of Alzheimer's disease (AD). The central role …

Alzheimer's disease (AD) is the most common type of dementia and a neurodegenerative
disorder characterized by memory deficits especially forgetting recent information, recall …

An increasing number of studies show that both inflammation and neural plasticity act as key
players in the vulnerability and recovery from psychiatric disorders and neurodegenerative …

Early therapeutic interventions are essential to prevent Alzheimer Disease (AD). The
association of several inflammation-related genetic markers with AD and the early activation …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that deteriorates
cognitive function. Patients with AD generally exhibit neuroinflammation, elevated beta …