This review presents evidence for two overlapping yet distinctive clinical types of sickle cell
disease. The basis of one is the vaso-occlusive crisis; the other is the consequence of …

Acute chest syndrome (ACS) is a frequent cause of acute lung disease in children with sickle
cell disease (SCD). Patients may present with ACS or may develop this complication during …

In spite of significant strides in the treatment of sickle cell disease (SCD), SCD crises are still
responsible for high morbidity and early mortality. While most patients initially seek care in …

Sickle cell disease (SCD) is a common monogenetic disorder with high associated morbidity
and mortality. The pulmonary complications of SCD are of particular importance, as acute …

Pain and acute chest syndrome (ACS) episodes are 2 of the most common causes of
hospitalization in children with sickle cell anemia (SCA). However, very few potentially …

Rationale: Pulmonary complications of sickle cell anemia (Hb-SS) commonly cause
morbidity, yet few large studies of pulmonary function tests (PFTs) in this population have …

Sickle cell disease is an autosomal recessive, multisystem disorder, characterised by
chronic haemolytic anaemia, painful episodes of vaso-occlusion, progressive organ failure …

Sickle cell anemia (SCA or SS homozygous sickle cell disease) is an inherited blood
disorder caused by single nucleotide substitution in the ß-globin gene that renders their …

An analysis of a prospective cohort of individuals with sickle cell anemia (SCA), enrolled
from birth through adulthood, was conducted to determine if asthma is a risk factor for death …

Secondary pulmonary hypertension (PH) is emerging as one of the leading causes of
mortality and morbidity in patients with hemolytic anemias such as sickle cell disease (SCD) …