The current state and future directions of RNAi-based therapeutics

RL Setten, JJ Rossi, S Han - Nature reviews Drug discovery, 2019 - nature.com
The RNA interference (RNAi) pathway regulates mRNA stability and translation in nearly all
human cells. Small double-stranded RNA molecules can efficiently trigger RNAi silencing of …

Compositions and methods for selection of nucleic acids

TT Pham, YC Tsai, J Korlach, TA Clark… - US Patent …, 2020 - Google Patents
Methods are provided for reducing the complexity of a population of nucleic acids prior to
performing an analysis of the nucleic acids, eg, sequence analysis. The methods result in a …

Conditional-siRNAS and uses thereof in treating acute myeloid leukemia

G Marcucci, YH Kuo, SP Han, L Scherer… - US Patent …, 2023 - Google Patents
US11643659B2 - Conditional-siRNAS and uses thereof in treating acute myeloid leukemia -
Google Patents US11643659B2 - Conditional-siRNAS and uses thereof in treating acute …

Programmable conditional SIRNAS and uses thereof

SP Han, WA Goddard III, MBHAJ SALAH… - US Patent …, 2024 - Google Patents
Disclosed herein are programmable, conditionally activated small interfering RNA constructs
(Cond-siRNAs) and methods of making and using the same as therapeutic agents. The …

Rna/dna hybrid nanoparticles modified with single stranded rna toeholds and uses thereof

BA Shapiro, KA Afonin, MD Viard… - US Patent App. 17 …, 2021 - Google Patents
US20210162066A1 - Rna/dna hybrid nanoparticles modified with single stranded rna toeholds
and uses thereof - Google Patents US20210162066A1 - Rna/dna hybrid nanoparticles modified …

Web page spectroscopy

AL Zaifman, JM Mocenigo - US Patent 11,582,254, 2023 - Google Patents
US11582254B2 - Web page spectroscopy - Google Patents US11582254B2 - Web page
spectroscopy - Google Patents Web page spectroscopy Download PDF Info Publication …

Compositions and methods for selection of nucleic acids

TT Pham, YC Tsai, J Korlach, TA Clark… - US Patent …, 2023 - Google Patents
5, 324632 A 6/1994 Weisburg et al. 5352604 A 10/1994 Wilson et al. 5,376.528 A 12/1994
King et al. 5, 587305 A 12/1996 Briggs et al. 5,707.8 11 A 1/1998 Ferrin et al. 5,710.000 A …

Web page spectroscopy

AL Zaifman, JM Mocenigo - US Patent 10,834,112, 2020 - Google Patents
Facilitating web page spectroscopy in a communications network is provided herein. A
system can comprise a processor and a memory that stores executable instructions that …

CONDITIONAL-siRNAS AND USES THEREOF IN TREATING CARDIAC HYERTROPHY

DAS Saumya, AMS GARICANO, SP Han, L Scherer… - 2019 - Google Patents
WO2019033079A1 - CONDITIONAL-siRNAS AND USES THEREOF IN TREATING CARDIAC
HYERTROPHY - Google Patents WO2019033079A1 - CONDITIONAL-siRNAS AND USES …