Large-scale genome-mining analyses have identified an enormous number of cryptic
biosynthetic gene clusters (BGCs) as a great source of novel bioactive natural products …

Bacteria in marine biofilms are a rich reservoir of natural products. To facilitate novel
secondary metabolite discovery, we investigated the metabolic profile of a marine biofilm …

Abstract The 2, 5-diketopiperazines are a prominent class of bioactive molecules. The
nocardioazines are actinomycete natural products that feature a pyrroloindoline …

UbiA-type prenyltransferases (PTases) are significant enzymes that lead to structurally
diverse meroterpenoids. Herein, we report the identification and characterization of an …

Drimentines (DMTs) are a family of bacterial alkaloids featuring a 2, 5-diketopiperazine (2, 5-
DKP) ring with diverse bioactivities. In this study, we characterized the biosynthetic pathway …

环二肽(cyclodipeptide, CDP) 是一类由2 个α-氨基酸缩合而成的最小环肽分子,
也可称为二酮哌嗪类化合物(diketopiperazines, DKPs). CDP 具有稳定的DKP 环状骨架结构 …

Natural products (NPs) derived from secondary metabolism of living organisms play a
pivotal role in drug discovery, especially for the treatment of cancer and infectious diseases …

Muchos de los compuestos bioactivos (fármacos) utilizados en medicina, veterinaria o
agricultura son compuestos naturales, suponiendo más del 40% de los fármacos en …