The review covers various aspects of fluorinated cycloalkyl (C3− C7) building blocks for drug
discovery, including their synthesis, key physicochemical properties, and biological and …

The approval in 2021 of a disease-modifying treatment for Alzheimer's disease should have
been hailed as the most important advance in neurology of the century, validating the wider …

Parkinson's disease (PD) is the second most prevalent neurodegenerative disease of the
central nervous system, with an estimated 5,000,000 cases worldwide. PD pathology is …

Activated Abelson non-receptor tyrosine kinase (c-Abl) plays a harmful role in
neurodegenerative conditions such as Parkinson's disease (PD). Inhibition of c-Abl is …

Tacrine was the first approved drug by the FDA for the treatment of Alzheimer's disease (AD)
but was withdrawn from the market due to its dose-dependent hepatotoxicity. Herein, we …

Parkinson's disease is the second most common neurodegenerative disorder. Although it is
clear that dopaminergic neurons degenerate, the underlying molecular mechanisms are still …

Parkinson's disease (PD) patients not only show motor features such as bradykinesia,
tremor, and rigidity but also non-motor features such as anxiety, depression, psychosis …

c-Abl phosphorylation primes PARIS for neurodegeneration | Brain | Oxford Academic Skip to
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Characterization of the phosphomimetic mutant Y39E of α-Synuclein Page 1 Characterization
of the phosphomimetic mutant Y39E of α-Synuclein Dissertation for the award of the degree …

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