Pyrazinamide (PZA) is a unique antituberculosis (anti-TB) drug that plays a key role in
shortening TB therapy. PZA kills nonreplicating persisters that other TB drugs fail to kill …

Since the discovery of the tubercle bacillus by Robert Koch in 1882 (110), a greater
understanding of the dynamics and survival mechanisms of this pathogen has led to more …

Tuberculosis continues to be a global health threat. Pyrazinamide (PZA) is an important first-
line drug in multidrug-resistant tuberculosis treatment. The emergence of strains resistant to …

Current machine learning classifiers have successfully been applied to whole-genome
sequencing data to identify genetic determinants of antimicrobial resistance (AMR), but they …

Thirty-four pyrazinamide-resistant and 37 pyrazinamide-susceptible Mycobacterium
tuberculosis complex strains were analyzed for pncA gene mutations. None of the sensitive …

Pyrazinamidase (PncA) activates the first-line antituberculous drug pyrazinamide into
pyrazinoic acid. The crystal structure of the Mycobacterium tuberculosis PncA protein has …

Tuberculosis treatment includes broad-spectrum antibiotics such as rifampicin, streptomycin
and fluoroquinolones, which are also used against other pathogenic bacteria. We …

Pyrazinamide (PZA) is a first-line antitubercular drug known for its activity against persistent
Mycobacterium tuberculosis bacilli. We set out to systematically determine the PZA …

Ralstonia eutropha H16 is capable of growth and polyhydroxyalkanoate production on plant
oils and fatty acids. However, little is known about the triacylglycerol and fatty acid …

Recent studies in addition to studies based on whole genome sequencing (WGS) of clinical
isolates of Mycobacterium tuberculosis (MTB) from diverse geographical regions have …