Mechanisms of pyrazinamide action and resistance
Pyrazinamide (PZA) is a unique antituberculosis (anti-TB) drug that plays a key role in
shortening TB therapy. PZA kills nonreplicating persisters that other TB drugs fail to kill …
shortening TB therapy. PZA kills nonreplicating persisters that other TB drugs fail to kill …
A balancing act: efflux/influx in mycobacterial drug resistance
GE Louw, RM Warren, NC Gey van Pittius… - Antimicrobial agents …, 2009 - Am Soc Microbiol
Since the discovery of the tubercle bacillus by Robert Koch in 1882 (110), a greater
understanding of the dynamics and survival mechanisms of this pathogen has led to more …
understanding of the dynamics and survival mechanisms of this pathogen has led to more …
Drug resistance mechanism of PncA in Mycobacterium tuberculosis
V Rajendran, R Sethumadhavan - Journal of Biomolecular …, 2014 - Taylor & Francis
Tuberculosis continues to be a global health threat. Pyrazinamide (PZA) is an important first-
line drug in multidrug-resistant tuberculosis treatment. The emergence of strains resistant to …
line drug in multidrug-resistant tuberculosis treatment. The emergence of strains resistant to …
A biochemically-interpretable machine learning classifier for microbial GWAS
Current machine learning classifiers have successfully been applied to whole-genome
sequencing data to identify genetic determinants of antimicrobial resistance (AMR), but they …
sequencing data to identify genetic determinants of antimicrobial resistance (AMR), but they …
Pyrazinamide Resistance and pncA Gene Mutations in Mycobacterium tuberculosis
P Juréen, J Werngren, JC Toro… - Antimicrobial agents and …, 2008 - Am Soc Microbiol
Thirty-four pyrazinamide-resistant and 37 pyrazinamide-susceptible Mycobacterium
tuberculosis complex strains were analyzed for pncA gene mutations. None of the sensitive …
tuberculosis complex strains were analyzed for pncA gene mutations. None of the sensitive …
Crystal Structure of the Pyrazinamidase of Mycobacterium tuberculosis: Insights into Natural and Acquired Resistance to Pyrazinamide
S Petrella, N Gelus-Ziental, A Maudry, C Laurans… - PloS one, 2011 - journals.plos.org
Pyrazinamidase (PncA) activates the first-line antituberculous drug pyrazinamide into
pyrazinoic acid. The crystal structure of the Mycobacterium tuberculosis PncA protein has …
pyrazinoic acid. The crystal structure of the Mycobacterium tuberculosis PncA protein has …
Survey of drug resistance associated gene mutations in Mycobacterium tuberculosis, ESKAPE and other bacterial species
Tuberculosis treatment includes broad-spectrum antibiotics such as rifampicin, streptomycin
and fluoroquinolones, which are also used against other pathogenic bacteria. We …
and fluoroquinolones, which are also used against other pathogenic bacteria. We …
Systematic analysis of pyrazinamide-resistant spontaneous mutants and clinical isolates of Mycobacterium tuberculosis
K Stoffels, V Mathys, M Fauville-Dufaux… - Antimicrobial agents …, 2012 - Am Soc Microbiol
Pyrazinamide (PZA) is a first-line antitubercular drug known for its activity against persistent
Mycobacterium tuberculosis bacilli. We set out to systematically determine the PZA …
Mycobacterium tuberculosis bacilli. We set out to systematically determine the PZA …
Elucidation of β-Oxidation Pathways in Ralstonia eutropha H16 by Examination of Global Gene Expression
CJ Brigham, CF Budde, JW Holder, Q Zeng… - Journal of …, 2010 - Am Soc Microbiol
Ralstonia eutropha H16 is capable of growth and polyhydroxyalkanoate production on plant
oils and fatty acids. However, little is known about the triacylglycerol and fatty acid …
oils and fatty acids. However, little is known about the triacylglycerol and fatty acid …
Molecular mechanisms of action, resistance, detection to the first-line anti tuberculosis drugs: Rifampicin and pyrazinamide in the post whole genome sequencing era
Recent studies in addition to studies based on whole genome sequencing (WGS) of clinical
isolates of Mycobacterium tuberculosis (MTB) from diverse geographical regions have …
isolates of Mycobacterium tuberculosis (MTB) from diverse geographical regions have …