echocardiogram) may be expected to facilitate the identification of patients with chest pain of
an ischemic etiology (angina). In a patient presenting to the emergency department with …

This chapter provides an overview of statistical methods for genome-wide association
studies (GWAS) in animals, plants, and humans. The simplest form of GWAS, a marker-by …

We develop a Bayesian mixed linear model that simultaneously estimates single-nucleotide
polymorphism (SNP)-based heritability, polygenicity (proportion of SNPs with nonzero …

Scientists from nearly all disciplines face the problem of simultaneously evaluating many
hypotheses. Conducting multiple comparisons increases the likelihood that a non-negligible …

I analyze some criticisms made about the application of alpha‐inflation correction
procedures to repeated‐test tables in ecological studies. Common pitfalls during application …

Major depressive disorder (MDD) is a common complex trait with enormous public health
significance. As part of the Genetic Association Information Network initiative of the US …

Accounting for the genetic substructure of human populations has become a major practical
issue for studying complex genetic disorders. Allele frequency differences among ethnic …

False discovery rate control has become an essential tool in any study that has a very large
multiplicity problem. False discovery rate-controlling procedures have also been found to be …

Little is known for certain about the genetics of schizophrenia. The advent of genomewide
association has been widely anticipated as a promising means to identify reproducible DNA …

Background The recent completion of the swine genome sequencing project and
development of a high density porcine SNP array has made genome-wide association …