Executive summary Traumatic brain injury (TBI) has the highest incidence of all common
neurological disorders, and poses a substantial public health burden. TBI is increasingly …

Intracranial pressure (ICP) monitoring is now viewed as integral to the clinical care of many
life-threatening brain insults, such as severe traumatic brain injury, subarachnoid …

Background The indications for intracranial pressure (ICP) monitoring in patients with acute
brain injury and the effects of ICP on patients' outcomes are uncertain. The aims of this study …

Abstract Background While the Glasgow coma scale (GCS) is one of the strongest outcome
predictors, the current classification of traumatic brain injury (TBI) as 'mild','moderate'or …

Coma and disorders of consciousness (DoC) are highly prevalent and constitute a burden
for patients, families, and society worldwide. As part of the Curing Coma Campaign, the …

Background Large-scale studies are required to better characterise traumatic brain injury
(TBI) and to identify the most effective treatment approaches for TBI. However, evidence is …

Background In patients with severe brain injury, withdrawal of life-sustaining measures
(WLSM) is common in intensive care units (ICU). WLSM constitutes a dilemma: instituting …

Background Patients with traumatic brain injury are a heterogeneous population, and the
most severely injured individuals are often treated in an intensive care unit (ICU). The …

Existing methods to characterise the evolving condition of traumatic brain injury (TBI)
patients in the intensive care unit (ICU) do not capture the context necessary for …

Intracranial pressure monitoring enables the detection and treatment of intracranial
hypertension, a potentially lethal insult after traumatic brain injury. Despite its widespread …