Polycyclic aromatic hydrocarbons (PAHs) are a class of chemicals of considerable
environmental significance. PAHs are chemical contaminants of fused carbon and hydrogen …

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants
generated primarily during the incomplete combustion of organic materials (eg coal, oil …

Clustered somatic mutations are common in cancer genomes and previous analyses reveal
several types of clustered single-base substitutions, which include doublet-and multi-base …

Summary Whole-genome-sequencing (WGS) of human tumors has revealed distinct
mutation patterns that hint at the causative origins of cancer. We examined mutational …

Cancers are composed of populations of cells with distinct molecular and phenotypic
features, a phenomenon termed intratumor heterogeneity (ITH). ITH in lung cancers has not …

Quinones represent a class of toxicological intermediates, which can create a variety of
hazardous effects in vivo including, acute cytotoxicity, immunotoxicity, and carcinogenesis …

Lung adenocarcinoma, the most common subtype of non-small cell lung cancer, is
responsible for more than 500,000 deaths per year worldwide. Here, we report exome and …

The genome of a cancer cell carries somatic mutations that are the cumulative
consequences of the DNA damage and repair processes operative during the cellular …

All cancers carry somatic mutations. The patterns of mutation in cancer genomes reflect the
DNA damage and repair processes to which cancer cells and their precursors have been …

Reactive oxygen and nitrogen species have been implicated in diverse pathophysiological
conditions, including inflammation, neurodegenerative diseases and cancer. Accumulating …