One of the simplest organic functional groups, the alkyne, offers a broad canvas for the
design of cascade transformations in which up to three new bonds can be added to each of …

The metal-hydride hydrogen atom transfer (MHAT) reaction plays an important role in the
field of natural product synthesis. MHAT, as a powerful method, has been employed by …

Covering: January to December 2021 This review covers the literature published in 2021 for
marine natural products (MNPs), with 736 citations (724 for the period January to December …

There are numerous pyrazine and phenazine compounds that demonstrate biological
activities relevant to the treatment of disease. In this review, we discuss pyrazine and …

The first and asymmetric total synthesis of bufogargarizins A and B, two unusual and highly
oxygenated twin steroids with rearranged A/B rings, was achieved. The synthetically …

Steroids are highly prevalent structures in small‐molecule therapeutics, with the level of
oxidation being key to their biological activity and physicochemical properties. These C …

C–H bond oxidation is a powerful means for oxygen incorporation in organic molecules. Its
use results in fast structural diversification and in a new way of thinking about retrosynthetic …

The first asymmetric total synthesis of the monoterpenoid indole alkaloid arboduridine has
been accomplished. The tricyclic A/B/D ring system was constructed by an enantioselective …

Sterol-binding proteins are important regulators of lipid homeostasis and membrane
integrity; however, the discovery of selective modulators can be challenging due to structural …

Herein we disclose an iron-catalyzed method for stereoselective synthesis of
multisubstituted cyclic ketones containing a synthetically challenging quaternary carbon …