Advances in TRP channel drug discovery: from target validation to clinical studies

AP Koivisto, MG Belvisi, R Gaudet… - Nature reviews Drug …, 2022 - nature.com
Transient receptor potential (TRP) channels are multifunctional signalling molecules with
many roles in sensory perception and cellular physiology. Therefore, it is not surprising that …

How plant hormones mediate salt stress responses

Z Yu, X Duan, L Luo, S Dai, Z Ding, G Xia - Trends in plant science, 2020 - cell.com
Salt stress is one of the major environmental stresses limiting plant growth and productivity.
To adapt to salt stress, plants have developed various strategies to integrate exogenous …

International consensus statement on allergy and rhinology: Allergic rhinitis–2023

SK Wise, C Damask, LT Roland, C Ebert… - International forum of …, 2023 - Wiley Online Library
Background In the 5 years that have passed since the publication of the 2018 International
Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR‐Allergic Rhinitis …

Advances and challenges in uncovering cold tolerance regulatory mechanisms in plants

Y Ding, Y Shi, S Yang - New Phytologist, 2019 - Wiley Online Library
Contents Summary I. Introduction II. Cold stress and physiological responses in plants III.
Sensing of cold signals in plants IV. Messenger molecules involved in cold signal …

Single-nucleus transcriptomic analysis of human dorsal root ganglion neurons

MQ Nguyen, LJ von Buchholtz, AN Reker, NJP Ryba… - Elife, 2021 - elifesciences.org
Somatosensory neurons with cell bodies in the dorsal root ganglia (DRG) project to the skin,
muscles, bones, and viscera to detect touch and temperature as well as to mediate …

Brown adipose tissue—a translational perspective

AC Carpentier, DP Blondin, F Haman… - Endocrine …, 2023 - academic.oup.com
Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

The emergence of transcriptional identity in somatosensory neurons

N Sharma, K Flaherty, K Lezgiyeva, DE Wagner… - Nature, 2020 - nature.com
More than twelve morphologically and physiologically distinct subtypes of primary
somatosensory neuron report salient features of our internal and external environments,,–. It …

[HTML][HTML] Methods used to evaluate pain behaviors in rodents

JR Deuis, LS Dvorakova, I Vetter - Frontiers in molecular …, 2017 - frontiersin.org
Rodents are commonly used to study the pathophysiological mechanisms of pain as studies
in humans may be difficult to perform and ethically limited. As pain cannot be directly …

[HTML][HTML] Pathophysiology of migraine: a disorder of sensory processing

PJ Goadsby, PR Holland… - Physiological …, 2017 - journals.physiology.org
Plaguing humans for more than two millennia, manifest on every continent studied, and with
more than one billion patients having an attack in any year, migraine stands as the sixth …

[PDF][PDF] Regulation of body temperature by the nervous system

CL Tan, ZA Knight - Neuron, 2018 - cell.com
The regulation of body temperature is one of the most critical functions of the nervous
system. Here we review our current understanding of thermoregulation in mammals. We …