Streptococcus pneumoniae is a human pathobiont possessing a diverse array of
multifunctional proteins essential for bacterial fitness and virulence. Gene expression is …

Pathogenic streptococcal species are responsible for a broad spectrum of human diseases
ranging from non-invasive and localized infections to more aggressive and life-threatening …

The molecular basis of the pathogenesis of the opportunistic invasive infections caused by
isolates of the Gemella genus remains largely unknown. Moreover, inconsistencies in the …

Wall teichoic acids (WTAs) are charged glycopolymers containing phosphodiester-linked
polyol units and represent one of the major components of Gram-positive cell envelope …

Competence for genetic transformation is a differentiation program during which exogenous
DNA is imported into the cell and integrated into the chromosome. In Streptococcus …

In the human pathogen Streptococcus pneumoniae, the gene regulatory circuit leading to
the transient state of competence for natural transformation is based on production of an …

Chromosomally encoded Type II Toxin–Antitoxin operons are ubiquitous in bacteria and
archaea. Antitoxins neutralize the toxic effect of cognate Toxins by protein–protein …

Global transcriptional regulators are prevalent in gram-positive pathogens. The
transcriptional regulators of the Mga/AtxA family regulate target gene expression by directly …

RNases perform indispensable functions in regulating gene expression in many bacterial
pathogens by processing and/or degrading RNAs. Despite the pivotal role of RNases in …

Cells respond to genome damage by inducing restorative programs, typified by the SOS
response of Escherichia coli. Streptococcus pneumoniae (the pneumococcus), with no …