NATs at a glance
Most proteins receive an acetyl group at the N terminus while in their nascency as the result
of modification by co-translationally acting N-terminal acetyltransferases (NATs). The N …
of modification by co-translationally acting N-terminal acetyltransferases (NATs). The N …
The biological functions of Naa10—from amino-terminal acetylation to human disease
MJ Dörfel, GJ Lyon - Gene, 2015 - Elsevier
N-terminal acetylation (NTA) is one of the most abundant protein modifications known, and
the N-terminal acetyltransferase (NAT) machinery is conserved throughout all Eukarya. Over …
the N-terminal acetyltransferase (NAT) machinery is conserved throughout all Eukarya. Over …
NatF contributes to an evolutionary shift in protein N-terminal acetylation and is important for normal chromosome segregation
P Van Damme, K Hole, A Pimenta-Marques… - PLoS …, 2011 - journals.plos.org
N-terminal acetylation (N-Ac) is a highly abundant eukaryotic protein modification.
Proteomics revealed a significant increase in the occurrence of N-Ac from lower to higher …
Proteomics revealed a significant increase in the occurrence of N-Ac from lower to higher …
Dual lysine and N‐terminal acetyltransferases reveal the complexity underpinning protein acetylation
WV Bienvenut, A Brünje, JB Boyer… - Molecular Systems …, 2020 - embopress.org
Protein acetylation is a highly frequent protein modification. However, comparatively little is
known about its enzymatic machinery. N‐α‐acetylation (NTA) and ε‐lysine acetylation (KA) …
known about its enzymatic machinery. N‐α‐acetylation (NTA) and ε‐lysine acetylation (KA) …
Proteome-derived peptide libraries allow detailed analysis of the substrate specificities of Nα-acetyltransferases and point to hNaa10p as the post-translational actin …
P Van Damme, R Evjenth, H Foyn, K Demeyer… - Molecular & Cellular …, 2011 - ASBMB
The impact of N α-terminal acetylation on protein stability and protein function in general
recently acquired renewed and increasing attention. Although the substrate specificity profile …
recently acquired renewed and increasing attention. Although the substrate specificity profile …
The chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation
T Arnesen, KK Starheim, P Van Damme… - … and cellular biology, 2010 - Taylor & Francis
The human NatA protein Nα-terminal-acetyltransferase complex is responsible for
cotranslational N-terminal acetylation of proteins with Ser, Ala, Thr, Gly, and Val N termini …
cotranslational N-terminal acetylation of proteins with Ser, Ala, Thr, Gly, and Val N termini …
A synopsis of eukaryotic Nα-terminal acetyltransferases: nomenclature, subunits and substrates
B Polevoda, T Arnesen, F Sherman - BMC proceedings, 2009 - Springer
A synopsis of eukaryotic Nα-terminal acetyltransferases: nomenclature, subunits and substrates
| BMC Proceedings Skip to main content SpringerLink Account Menu Find a journal Publish …
| BMC Proceedings Skip to main content SpringerLink Account Menu Find a journal Publish …
NatB-mediated N-terminal acetylation affects growth and biotic stress responses
M Huber, WV Bienvenut, E Linster, I Stephan… - Plant …, 2020 - academic.oup.com
N∝-terminal acetylation (NTA) is one of the most abundant protein modifications in
eukaryotes. In humans, NTA is catalyzed by seven Nα-acetyltransferases (NatA–F and …
eukaryotes. In humans, NTA is catalyzed by seven Nα-acetyltransferases (NatA–F and …
Mechanisms of congenital heart disease caused by NAA15 haploinsufficiency
Rationale: NAA15 (N-alpha-acetyltransferase 15) is a component of the NatA (N-terminal
acetyltransferase complex). The mechanism by which NAA15 haploinsufficiency causes …
acetyltransferase complex). The mechanism by which NAA15 haploinsufficiency causes …
Protein alpha‐N‐acetylation studied by N‐terminomics
Cotranslational protein N‐terminal modifications, including proteolytic maturation such as
initiator methionine excision by methionine aminopeptidases and N‐terminal blocking, occur …
initiator methionine excision by methionine aminopeptidases and N‐terminal blocking, occur …