The observation that heart failure with reduced ejection fraction is associated with elevated
circulating levels of pro-inflammatory cytokines opened a new area of research that has …

Heart failure (HF) is a culmination of pathological processes presenting with debilitating
symptoms that highlight a complex interplay between immunological, hormonal, and …

Frailty, a clinical syndrome that typically occurs in older adults, implies a reduced ability to
tolerate biological stressors. Frailty accompanies many age‐related diseases but can also …

Aims Identification of signatures of immune cells at single-cell level may provide novel
insights into changes of immune-related disorders. Therefore, we used single-cell RNA …

Over the past 30 years, the field of cardioimmunology has moved from being dismissed as a
field that was chasing an epiphenomenon of little biological consequence to a scientific …

Background: Monocyte subsets in humans, ie, classical (CM), intermediate (IM), and non-
classical monocytes (NCM), are thought to differentially contribute to the pathogenesis of …

Low-grade chronic inflammation underlies the development of the most dangerous
cardiometabolic disorders including type 2 diabetes and its vascular complications. In …

Purpose Acute heart failure (AHF) syndromes manifest increased inflammation and vascular
dysfunction; however, mechanisms that integrate the two in AHF remain largely unknown …

Aims Inflammation has emerged as a potential key pathophysiological mechanism in heart
failure (HF) in general and acute HF (AHF) specifically, with inflammatory biomarkers shown …

Acute heart failure (AHF) is a complex disease involving a variety of pathophysiology. For
many years, the pathogenesis and prognosis of patients with AHF have been believed to be …