A review on anticancer potential of bioactive heterocycle quinoline

O Afzal, S Kumar, MR Haider, MR Ali, R Kumar… - European Journal of …, 2015 - Elsevier
The advent of Camptothecin added a new dimension in the field anticancer drug
development containing quinoline motif. Quinoline scaffold plays an important role in …

[HTML][HTML] Comprehensive review on current developments of quinoline-based anticancer agents

S Jain, V Chandra, PK Jain, K Pathak, D Pathak… - Arabian Journal of …, 2019 - Elsevier
Among heterocyclic compounds, quinoline scaffold has become an important construction
motif for the development of new drugs. Quinoline and its derivatives possess many types of …

NAD (P) H: quinone oxidoreductase 1 (NQO1) as a therapeutic and diagnostic target in cancer

K Zhang, D Chen, K Ma, X Wu, H Hao… - Journal of Medicinal …, 2018 - ACS Publications
NAD (P) H: quinone oxidoreductase 1 (NQO1) is a two-electron reductase responsible for
detoxification of quinones and also bioactivation of certain quinones. It is abnormally …

Synthetic approaches to 3-(2-nitroalkyl) indoles and their use to access tryptamines and related bioactive compounds

S Lancianesi, A Palmieri, M Petrini - Chemical Reviews, 2014 - ACS Publications
The assembly of architecturally complex alkaloids embedding the indole nucleus is of
paramount importance for the target oriented synthesis of biologically active molecules. 1 A …

Turning on catalysis: incorporation of a hydrogen-bond-donating squaramide moiety into a Zr metal–organic framework

CM McGuirk, MJ Katz, CL Stern… - Journal of the …, 2015 - ACS Publications
Herein, we demonstrate that the incorporation of an acidic hydrogen-bond-donating
squaramide moiety into a porous UiO-67 metal–organic framework (MOF) derivative leads to …

Biological activities of polypyridyl-type ligands: implications for bioinorganic chemistry and light-activated metal complexes

AC Hachey, D Havrylyuk, EC Glazer - Current opinion in chemical biology, 2021 - Elsevier
Polypyridyl coordinating ligands are common in metal complexes used in medicinal
inorganic chemistry. These ligands possess intrinsic cytotoxicity, but detailed data on this …

Urea-engineering mediated hydrogen-bond donating Friedel–Crafts alkylation of indoles and nitroalkenes in a dual-functionalized microporous metal–organic …

M Singh, S Neogi - Inorganic Chemistry Frontiers, 2022 - pubs.rsc.org
As an effective alternative to Lewis-acid activation, hydrogen-bond donating (HBD) organo-
catalysis represents a powerful construction tool for important classes of carbon–carbon …

Synthesis of quinones with highlighted biological applications: A critical update on the strategies towards bioactive compounds with emphasis on lapachones

EN da Silva Júnior, GAM Jardim, C Jacob… - European Journal of …, 2019 - Elsevier
Naphthoquinones are of key importance in organic synthesis and medicinal chemistry. In the
last few years, various synthetic routes have been developed to prepare bioactive …

Synthesis of 8-hydroxyquinoline derivatives as novel antitumor agents

SH Chan, CH Chui, SW Chan, SHL Kok… - ACS medicinal …, 2013 - ACS Publications
This letter describes the preparation of quinoline derivatives and their cytotoxic potentials
toward human carcinoma cell lines. Among the selected compounds, 8-hydroxy-2 …

Highly Active La (III)‐Based Metal‐Organic Framework as a Heterogeneous Lewis Acid Catalyst for Friedel‐Crafts Alkylation

JQ Wu, XY Wu, JM Lu, Q Shi… - Chemistry–A European …, 2022 - Wiley Online Library
In this study, a novel La (III)‐based two‐dimensional (2D) metal‐organic framework,[La2/3
(qptca) 1/2](referred to as SLX‐2), from LaCl3 and 1, 1′: 4′, 1′′: 4′′, 1 …